炎症性肠病患者血清胆汁酸谱的研究  

Serum Bile Acid Profile in Patients with Inflammatory Bowel Disease

作　　者：陆霞娟 周敏[2] 瞿春莹[2] 葛文松[2] 陈颖伟[2] LU Xiajuan ZHOU Min QU Chunying GE Wensong CHEN Yingwei(Department of Gastroenterology, Kongjiang Hospital of Shanghai Yangpu District, Shanghai （200093 Department of Gastroenterology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai)

机构地区：[1]上海市杨浦区控江医院消化内科,200093 [2]上海交通大学医学院附属新华医院消化内科

出　　处：《胃肠病学》2017年第5期297-300,共4页Chinese Journal of Gastroenterology

基　　金：国家自然基金项目(批准号81370485)资助

摘　　要：背景:炎症性肠病(IBD)发病率不断升高,其病因和发病机制尚未完全明确。研究发现,胆汁酸代谢紊乱在实验性结肠炎的病理进程中起重要作用,但其与IBD发病的相关性尚未见报道。目的:探讨IBD患者血清胆汁酸谱的变化。方法:选取上海新华医院7名健康对照、15例溃疡性结肠炎(UC)和16例克罗恩病(CD),采用高效液相色谱-质谱法检测血清胆汁酸谱。结果:与对照组相比,UC和CD患者血清初级胆汁酸胆酸(CA)、鹅去氧胆酸(CDCA)、甘氨胆酸(GCA)、牛磺胆酸(TCA)、甘氨鹅去氧胆酸(GCDCA)含量无明显差异(P>0.05);UC患者次级胆汁酸去氧胆酸(DCA)含量显著降低(P<0.05),CD患者甘氨去氧胆酸(GDCA)和牛磺去氧胆酸(TDCA)含量显著降低(P<0.05),UC和CD患者血清石胆酸(LCA)显著降低(P<0.05)。结论:IBD患者血清胆汁酸谱发生显著改变,提示其可能参与IBD病理进程。Background： The incidence of inflammatory bowel disease （IBD） is increasing in recent years, and the etiology and pathogenesis of IBD remain unclear.Studies showed that disorder of bile acid metabolism plays an important role in the pathological process of experimental colitis.However, serum bile acid profile in IBD patients has not been reported.Aims： To investigate the changes of serum bile acid profile in patients with IBD.Methods： Seven healthy controls, 15 patients with ulcerative colitis （UC） and 16 patients with Crohn＆#39;s disease （CD） at Shanghai Xin Hua Hospital were enrolled.High-performance liquid chromatography-mass spectrometry was used to determine serum bile acid profile.Results： No significant differences in serum concentrations of primary bile acid cholic acid （CA）, chenodeoxycholic acid （CDCA）, glycocholic acid （GCA）, taurocholic acid （TCA）, glycochenodeoxycholic acid （GCDCA） were found between UC or CD and controls （P〉0.05）.Compared with controls, serum concentration of secondary bile acid deoxycholic acid （DCA） in UC patients was significantly decreased （P〈0.05）, glycodeoxycholic acid （GDCA）, taurodeoxycholic acid （TDCA） in CD patients were significantly decreased （P〈0.05）, serum concentration of lithocholic acid （LCA） in UC and CD patients was significantly decreased （P〈0.05）.Conclusions： The serum bile acid profile in IBD patients is significantly changed, which suggests that it may be involved in the pathological process of IBD.

关 键 词：胆汁酸类和盐类 炎症性肠病 结肠炎 溃疡性 CROHN病 

分 类 号：R574[医药卫生—消化系统]