CMTM3在幽门螺杆菌感染慢性胃炎中的表达及其意义  

Expression and Significance of CMTM3 in Helicobacter pylori Infected Chronic Gastritis

作　　者：杨淑丽[1,2] 韩文玲[3] 张贺军[1] 郭燕磊 原婉琼 王文静[1] 丁士刚[1] YANG Shuli HAN Wenling ZHANG Hejun GUO Yanlei YUAN Wanqiong WANG Wenjing DING Shigang(Department of Gastroenterology, Peking University Third Hospital, Beijing （100191 School of Medical and Nursing, Suzhou Vocational Health College, Suzhou, Jiangsu Province Department of Immunology, Peking University School of Basic Medical Sciences, Beijing)

机构地区：[1]北京大学第三医院消化内科,100191 [2]苏州卫生职业技术学院医护学院 [3]北京大学基础医学院免疫学系

出　　处：《胃肠病学》2017年第5期301-303,共3页Chinese Journal of Gastroenterology

基　　金：北京市科技计划项目(A57405-16);江苏省高等职业院校教师高级访问学者计划项目(2015FX074)

摘　　要：背景:趋化素样因子超家族(CMTM)参与炎症、肿瘤等多种疾病的发生、发展过程。目前对CMTM3的研究主要集中在其肿瘤抑制作用方面。目的:探讨CMTM3在幽门螺杆菌(Hp)感染慢性胃炎中的表达及其意义。方法:选取Hp阳性和阴性慢性胃炎患者各30例,以免疫组化法检测胃黏膜CMTM3和白细胞介素-6(IL-6)表达,分析两者表达的相关性。结果:与Hp阴性慢性胃炎患者相比,Hp阳性慢性胃炎患者胃黏膜中CMTM3和IL-6阳性表达率均显著增高(CMTM3:63.3%对30.0%,P<0.05;IL-6:73.3%对13.3%,P<0.01)。在Hp阳性慢性胃炎患者中,CMTM3与IL-6的共表达率为53.3%(16/30),且两者表达部位一致;相关性分析显示两者呈显著正相关(r=0.58,P<0.05)。结论:CMTM3在Hp感染慢性胃炎胃黏膜中呈高表达,其可能与IL-6等炎症细胞因子共同参与了Hp感染慢性胃炎的发生、发展。Hp感染可能是引起CMTM3表达上调的机制之一。Background： CKLF-like MARVEL transmembrane domain containing （CMTM） superfamily is involved in the occurrence and development of inflammation, cancer and a variety of diseases.Human CMTM3 has been proposed as a putative tumor suppressor gene.Aims： To investigate the expression of CMTM3 in Helicobacter pylori （Hp） infection-related chronic gastritis and its significance.Methods： Sixty cases of outpatients with chronic gastritis （30 Hp-positive and 30 Hp-negative） were enrolled for detection of CMTM3 and interleukin-6 （IL-6） expressions in gastric mucosa by immunohistochemistry.The correlation of expressions of CMTM3 and IL-6 was analyzed.Results： The positivity rates of CMTM3 and IL-6 in gastric mucosa were significantly higher in Hp-positive chronic gastritis than in Hp-negative ones （CMTM3： 63.3% vs.30.0%, P〈0.05;IL-6： 73.3% vs.13.3%, P〈0.01）.In patients with Hp-positive chronic gastritis, CMTM3 and IL-6 were co-expressed in 53.3% （16/30） of the patients and localized in the same position.Expression of CMTM3 was positively correlated with IL-6 expression in Hp-positive chronic gastritis patients （r=0.58, P〈0.05）.Conclusions： CMTM3 is highly expressed in chronic gastritis patients with Hp infection.It may participate in the occurrence and development of Hp infection-related chronic gastritis with inflammatory cytokines such as IL-6.Hp infection might be one of the mechanisms involved in CMTM3 up-regulation.

关 键 词：幽门螺杆菌 胃炎 CMTM3 白细胞介素6 免疫组织化学 

分 类 号：R573.3[医药卫生—消化系统]