七叶神安片联合舒马普坦治疗中老年慢性偏头痛的临床效果观察  

Clinical observation on the treatment of Middle-Aged Chronic Migraine with Qiye Shenan tablet and Sumatriptan

作　　者：陶陈娟[1] 严伟伟 宋秋英[1] 王小川[1] 

机构地区：[1]杭州师范大学附属医院神经内科,浙江杭州310015 [2]杭州红十字会医院职业病科,浙江杭州310003

出　　处：《中国生化药物杂志》2017年第5期206-208,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的观察七叶神安片联合舒马普坦治疗中老年慢性偏头痛的临床效果。方法选取2015年7月~2016年12月杭州师范大学附属医院神经内科收治的124例老年慢性偏头痛患者为研究对象,将其根据随机原则分为2组,各62例。对照组给予舒马普坦进行治疗,观察组在此基础上加用七叶神安片。分析2组的疗效、相关指标以及不良反应。结果 （1）观察组治疗有效率为95.16%,高于对照组80.65%（P〈0.05）。（2）治疗后,观察组VAS评分和主要症状评分分别为（1.86±0.42、3.48±0.59）分,均低于对照组（3.19±0.50、5.06±0.64）分（均P〈0.05）。（3）治疗后,观察组血浆一氧化氮（NO）水平为（33.04±3.86）μmol/L,低于对照组（40.92±4.28）μmol/L（P〈0.05）。（4）观察组用药期间的不良反应为11.29%,低于对照组17.74%,但组间差异无统计学意义。结论七叶神安片能提高老年慢性偏头痛治疗效果,有效降低患者疼痛并改善相关症状,且用药安全。Objective To observe the clinical effect of Qiye Shenan tablet combined with sumatriptan in the treatment of middle-aged and elderly patients with chronic migraine.MethodsA total of 124 elderly patients with chronic migraine treated in our hospital from July 2015 to December 2015 were selected.The patients were divided into two groups according to the principle of randomization, with 62 cases in each group.The control group was treated with sumatriptan, The observation group was treated with Qiye Shenan tablet on this basis.The curative effect of the two groups, the relevant indicators and adverse reactions were analyzed.ResultsThe effective rate was 95.16% in the observation group, which was higher than that in the control group （80.65%, P〈0.05）.After treatment, the VAS score and the main symptom scores of the observation group were （1.86±0.42,3.48±0.59）, respectively, which were lower than those in the control group （3.19±0.50,5.06±0.64） （P〈0.05）.The level of nitric oxide （NO） in the observation group was （33.04±3.86）μmol/L, which was lower than that in the control group （40.92±4.28）μmol/L（P〈0.05）.The adverse reaction rate was 11.29% in the observation group, which was lower than that in the control group （17.74%）, but there was no significant difference between the two groups.ConclusionQiye Shenan tablet can improve the therapeutic effect of chronic migraine in the elderly, reduce the pain of the patients and improve the related symptoms, and the safety of medication.

关 键 词：七叶神安片 舒马普坦 中老年 慢性偏头痛 

分 类 号：R747.2[医药卫生—神经病学与精神病学]