埃索美拉唑与奥美拉唑治疗胃溃疡的疗效比较  

Efficiency comparison of Esomeprazole and Omeprazole in the treatment of gastric ulcer

作　　者：张蔚[1] 徐学田[1] 杨帆[1] 

机构地区：[1]固原市人民医院消化内科

出　　处：《中国生化药物杂志》2017年第5期232-233,共2页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的对比分析埃索美拉唑与奥美拉唑治疗胃溃疡的疗效以及治疗的方法,为胃溃疡的临床治疗提供参考。方法选取2014年2月~4月宁夏回族自治区固原市人民医院消化内科收治的80例胃溃疡患者为研究对象,随机分为观察组和对照组,各40例。对照组服用奥美拉唑治疗,观察组服用埃索美拉唑治疗,均接受3个疗程的治疗,观察2组患者治疗后身体情况的变化,分析胃痛的程度以及病症的变化,观察胃溃疡的愈合程度,分析2组患者的临床治疗效果。结果治疗后,观察组患者的恢复程度为100%,明显高于对照组的90%,差异有统计学意义（P〈0.05）。观察组患者的疼痛程度评分、药物使用效果评分明显低于对照组,差异有统计学意义（P〈0.05）。观察组不良反应发生率明显低于对照组,差异有统计学意义（P〈0.05）。结论埃索美拉唑治疗胃溃疡的疗效优于奥美拉唑,患者满意程度高,能够有效缩短患者伤口愈合时间,减少患者治疗时间,减轻医疗费用,且不良反应轻。Objective To compare the efficacy of esomeprazole and omeprazole in the treatment of gastric ulcer, and to provide a reference for the clinical treatment of gastric ulcer.Methods80 cases of gastric ulcer patients in our hospital from February to April 2014 were randomly divided into observation group and control group, with 40 cases in each group.The patients in the control group were treated with omeprazole,the patients in the observation group were treated with Esomeprazole, patients received three courses of treatment,the changes of body after treatment in two groups were observed, the degree of stomach pain and the changes of the condition were analyzed, the healing degree of gastric ulcer was observed, the clinical therapeutic effect of two groups was analyzed.ResultsAfter treatment, the recovery rate of the observation group was 100%, significantly higher than the control group 90%, the difference was statistically significant （P〈0.05）.The scores of pain in the observation group and the drug use score were significantly lower than those in the control group （P〈0.05）.The adverse reaction rate of the observation group was significantly lower than that of the control group, the difference was statistically significant （P〈0.05）.ConclusionThe efficiency of Esomeprazole in the treatment of gastric ulcer is better than omeprazole, patients with high satisfaction, can effectively shorten the wound healing time, reduce patient treatment time, reduce medical costs, and adverse reactions light.

关 键 词：埃索美拉唑 奥美拉唑 胃溃疡 临床疗效 

分 类 号：R573.1[医药卫生—消化系统]