普拉洛芬滴眼液对2型糖尿病伴干眼症患者溶菌酶、EGF和LF水平的影响  

Effects of pranoprofen eye drops on iysozyme, EGF and LF levels in type 2 diabetic patients with dry eye syndrome

作　　者：陈彦[1] 郑志斌[1] 黄慧慧[1] 

机构地区：[1]余姚市人民医院眼科

出　　处：《中国生化药物杂志》2017年第5期260-262,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨普拉洛芬滴眼液对2型糖尿病伴干眼症患者溶菌酶、EGF和LF水平的影响,并观察临床疗效。方法选取余姚市人民医院眼科2013年9月~2015年5月就诊的2型糖尿病伴干眼症患者70例,随机分为对照组和治疗组,每组35例。对照组采用人工泪液0.1 m L/次滴眼,6次/d治疗;治疗组在对照组基础上,采用普拉洛芬滴眼液0.15 m L/次滴眼,4次/d治疗。2组均以14 d为1个疗程,共治疗2个疗程。治疗结束后,比较治疗前后2组患者泪膜破裂时间、基础泪液分泌量、角膜荧光染色阳性率及临床疗效的变化。结果治疗组总有效率高于对照组（P〈0.05）;与治疗前相比,2组患者泪膜破裂时间延长、基础泪液分泌量及泪液中的溶菌酶、EGF及LF水平明显升高（P〈0.05）,角膜荧光染色阳性反应发生率降低（P〈0.05）;治疗后与对照组相比,治疗组患者泪膜破裂时间较长、基础泪液分泌量较高,溶菌酶、EGF及LF水平较高（P〈0.05）,角膜荧光染色阳性反应发生率较低（P〈0.05）。结论普拉洛芬滴眼液对2型糖尿病并发干眼症患者的治疗临床疗效良好,推测其机制与泪膜破裂时间的延长、基础泪液分泌量增加及溶菌酶、EGF及LF水平的升高有关。Objective To investigate the effect and clinical efficacy of pranoprofen eye drops on lysozyme, EGF and LF levels in type 2 diabetic patients with dry eye syndrome.Methods70 Type 2 diabetes patients with dry eye from department of ophthalmology, Yuyao People＇s Hospital of Zhejiang Province from September 2013 to May 2015.They were selected and randomly divided into the treatment group and the control group with 35 cases in each group.The control group were treated by artificial tears eye drops 0.1mL/time, 6 times/day treatment.The treatment group were treated on the base of the control group with pranoprofen eye drops 0.15mL/eye drops, 4 times/day treatment.2 groups were 14 days for 1 courses of treatment, a total of 2 courses of treatment.The tear break-up time, basal lacrimal secretion, corneal fluorescein staining positive rate and clinical efficacy were compared between two groups before and after treatment.ResultsWith the total effective rate in the treatment group,was higher than the control group（P〈0.05）.Compared with before treatment, the tear break-up time prolonged, basal lacrimal secretion, tear lysozyme, EGF and LF levels were higher（P〈0.05）, the positive reaction rate of corneal fluorescence staining was lower（P〈0.05）.Compared with the control group after treatment, the tear break-up time prolonged, basal lacrimal secretion, tear lysozyme, EGF and LF levels were higher（P〈0.05）, the positive reaction rate of corneal fluorescence staining was lower（P〈0.05）.ConclusionThe clinical efficacy of pranoprofen eye drops in type 2 diabetic patients with dry eye syndromeis good.It is speculated that the mechanism and tear break-up time prolonged, basal lacrimal secretion increase and lysozyme, epidermal growth factor（EGF）and the level of LF increased.

关 键 词：干眼症 2型糖尿病 普拉洛芬滴眼液 

分 类 号：R77[医药卫生—眼科]