人生长分化因子3、前列腺特异性抗原与黏蛋白1联合检测在乳腺癌诊断中的临床意义  

Clinical significance of detection of GDF3,PSA combined with MUC1 for diagnosis of breast cancer

作　　者：王琼 胡建军[2] 李艳霞 

机构地区：[1]浙江省绿城心血管病医院检验科,浙江杭州310012 [2]常山县人民医院检验科,浙江常山324299

出　　处：《中国生化药物杂志》2017年第5期388-390,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的探讨人生长分化因子3（growth differentiation factor 3,GDF3）、前列腺特异性抗原（prostate specific antigen,PSA）与黏蛋白1（mucin 1,MUC1）联合检测在乳腺癌诊断中的临床意义。方法选取2013年8月~2014年12月于绿城心血管病医院已确诊为乳腺癌的患者50例作为乳腺癌组;同期选取住院的乳腺良性疾病患者50例作为乳腺良性疾病组;同期选取体检中心体检的健康女性50例作为正常组。检测各组血清GDF3、PSA、MUC1和肿瘤标志物糖类抗原（carbohydrate antigen,CA）15-3、CA125、癌胚抗原（carcinoembryonic antigen,CEA）的表达水平,对比分析其敏感度、特异度和准确度。结果乳腺癌组血清GDF3、PSA、MUC1水平均高于良性乳腺疾病组和正常组（P〈0.05）,CA15-3、CA125、CEA水平均高于良性乳腺疾病组和正常组（P〈0.05）;PSA＋MUC1两两检测的敏感度、特异度、准确度均高于其他2组（P〈0.05）;血清GDF3、PSA、MUC1三者联合的敏感度、特异度、准确度高于单项检测以及两两检测（P〈0.05）。结论 GDF3联合检测PSA和MUC1对乳腺癌的早期诊断更有确诊意义。Objective To investigate the clinical significance of detection of growth differentiation factor 3（GDF3）, prostate specific antigen（PSA） combined with mucin 1（MUC1）for diagnosis of breast cancer.Methods50 cases of breast cancer were selected as the breast cancer group, 50 cases of benign breast disease were selected as the benign breast disease group, and 50 healthy people were selected as the normal group.GDF3, PSA, MUC1 and tumor markets carbohydrate antigen（CA）15-3,CA125,carcinoembryonic antigen（CEA） were detected, and sensitivity, specificity and accuracy were analyzed.ResultsCompared with benign breast disease group and normal group, GDF3, PSA and MUC1 in breast cancer group were higher（P〈0.05）, CA15-3, CA125 and CEA were higher（P〈0.05）.The sensitivity, specificity and accuracy of PSA＋MUC1 were higher than other group（P〈0.05）,the sensitivity, specificity and accuracy of combined detection of GDF3, PSA and MUC1 were higher（P〈0.05）.ConclusionDetection of GDF3 combined with MUC1 and PSA for early diagnosis of breast cancer has more diagnostic significance.

关 键 词：乳腺癌 人生长分化因子3 前列腺特异性抗原 黏蛋白1 肿瘤标志物 

分 类 号：R737.9[医药卫生—肿瘤]