bFGF和MMP9在鼻咽癌组织中的表达及其临床意义  

Expression and clinical significance of bFGF and MMP9 in nasopharyngeal carcinoma

作　　者：赵建夫[1] 陈文慧[1] 赵凤芝[1] 全强[1] 樊晶[1] 陈碧云[1] 张鼎[1] 徐萌[1] 

机构地区：[1]暨南大学附属第一医院肿瘤科,广东广州510632

出　　处：《中国病理生理杂志》2017年第6期1006-1011,共6页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金资助项目(No.81273814);广东省重大新药创制重大科技专项资助(No.2013A022100031);暨南大学附属第一医院科研培育项目

摘　　要：目的:探讨碱性成纤维细胞生长因子(bFGF)和基质金属蛋白酶9(MMP9)在鼻咽癌患者中的表达及其临床意义。方法:应用免疫组化方法检测289例鼻咽癌患者活检组织治疗前bFGF和MMP9的表达水平,并分析二者与鼻咽癌患者临床病理特征和预后的关系。结果:289例鼻咽癌组织bFGF和MMP9阳性表达率分别为71.3%和61.6%;bFGF和MMP9的阳性表达与鼻咽癌的N分期和临床分期有显著的相关性(P<0.05),且两者的高表达均与鼻咽癌的不良预后显著相关(P<0.01);在鼻咽癌组织中Spearman相关分析发现,bFGF的表达与MMP9的表达呈明显正相关(r=0.634,P<0.05);亚组分析表明,bFGF和MMP9表达水平均升高的鼻咽癌患者的预后最差。结论:bFGF和MMP9在鼻咽癌组织中的表达升高,且两者与鼻咽癌的不良预后明显相关,联合应用有可能成为鼻咽癌的诊断、治疗及判断预后的生物标志物。AIM： To detect the expression of basic fibroblast growth factor （bFGF） and matrix metalloprotei-nase 9 （ MMP9） in nasopharyngeal carcinoma （ NPC） and its correlation with clinicopathological features and prognosis ofthe patients. METHODS ： The expression of bFGF and MMP9 was detected by the method of SP immunohistochemical staining in biopsy tissues of NPC patients. The relationship between the expression and the clinical significance was ana-lyzed as well. RESULTS： In 289 cases of NPC patients, the positive rates of bFGF and MMP9 were 7 1 .3% and 6 1 .6% , respectively. Correlation analysis demonstrated that the expression rates of bFGF and MMP9 were both positively associated with N stage and clinical stage in NPC patients. The high expression rates of both bFGF and MMP9 were associated with poor overall survival and progression-free survival of NPC patients. Furthermore, the positive rate of bFGF was positively correlated with that of MMP9, and over-expression of both bFGF and MMP9 was correlated with the poorest survival out-comes in NPC patients. CONCLUSION ： bFGF and MMP9 are over-expressed in NPC tissues and significantly associated with NPC recurrence and poor outcome. The combined interpretation of bFGF and MMP9 expression levels leads to refine-ment of the risks for the NPC patients and could be chosen as the prognostic biomarkers.

关 键 词：鼻咽癌 碱性成纤维细胞生长因子 基质金属蛋白酶9 预后 生物标志物 

分 类 号：R730.23[医药卫生—肿瘤] R739.63[医药卫生—临床医学]