脑心通胶囊治疗急性脑梗死疗效及对细胞炎症因子、凝血功能和血液流变学的影响  

Effect of Naoxintong Capsule in Treatment of Acute Cerebral Infarction and Its Effect on Inflammatory Factors and Coagulation Function and Blood Rheology

作　　者：朱巍[1] 王志英[1] 鲍洪雅 骆晓兰 吴明亮[1] 

机构地区：[1]绍兴文理学院附属医院内科,浙江绍兴312000

出　　处：《中华中医药学刊》2017年第6期1607-1610,共4页Chinese Archives of Traditional Chinese Medicine

摘　　要：目的:探讨脑心通胶囊治疗急性脑梗死患者疗效及对细胞炎症因子、凝血功能和血液流变学的影响。方法:急性脑梗死患者98例按照随机数字表法分为治疗组49例与对照组49例。对照组患者采用常规西医治疗,治疗组在对照组基础上结合脑心通胶囊治疗。两组疗程均为4周。比较两组治疗疗效,治疗前后NIHSS评分、细胞炎症因子、凝血功能和血液流变学水平的影响,及不良反应发生情况。结果:治疗组总有效率(91.84%)高于对照组(73.47%),且有统计学意义(P<0.05);治疗组治疗后NIHSS评分低于对照组(t值=11.681,P<0.05);治疗组治疗后MCP-1和hs-CRP水平低于对照组(t值=18.060、10.528,P<0.05);治疗组治疗后PT、APTT水平水平高于对照组而D-二聚体水平低于对照组(t值=17.054、10.787、10.579,P<0.05);治疗组治疗后血浆黏度、全血黏度高切、全血黏度低切水平低于对照组(t值=6.869、5.754、7.609,P<0.05);两组肝肾功能、心电图、血常规均未见异常,且无明显药物不良反应。结论:脑心通胶囊治疗急性脑梗死患者疗效明显,可降低血清MCP-1和hs-CRP水平,改善患者凝血功能和血液流变学异常,具有重要研究意义。Objective： To investigate the effect of Naoxintong Capsule in the treatment of patients with acute cerebral infarction and its effect on inflammatory factors and coagulation function and blood rheology. Methods： Ninety-eight patients with acute cerebral infarction were randomly divided into treatment group（ n = 49） and control group（ n = 49）.The control group was treated with conventional western medicine treatment and the treatment groupon the basis of the control group used Naoxintong Capsule. The course of treatment was 4 weeks in two groups. The therapeutic effects of two groups were compared. The effects of NIHSS score,cytokines,coagulation and hemorheology levels before and after treatment and adverse reactions were observed. Results： The total effective rate of the treatment group（ 91. 84%） was higher than the control group＇s（ 73. 47%）（ P〈0. 05）. After treatment,NIHSS score of the treatment group was lower than the control group＇s（ t = 11. 681,P〈0. 05）. MCP-1 and hs-CRP levels after treatment in the treatment group were lower than the control group＇s（ t = 18. 060,10. 528,P〈0. 05）. PT and APTT levels in treatment group were higher than the control group＇s and two D-dimer levels were lower than the control group＇s（ t = 17. 054,10. 787,10. 579,P〈0. 05）. After treatment,the treatment group＇s plasma viscosity,whole blood viscosity and whole blood viscosity at low shear level were lower than the control group＇s（ t = 6. 869,5. 754,7. 609,P〈0. 05）. Two groups＇ liver and kidney function,electrocardiogram and blood routine examination showed no abnormality or no obvious adverse drug reaction.Conclusion： The effect of Naoxintong Capsule in the treatment of patients with acute cerebral infarction can significantly reduce the serum MCP-1 and hs-CRP levels,improve the coagulation function in patients with abnormal blood rheology and has the important research significance.

关 键 词：脑心通胶囊 急性脑梗死 疗效 细胞炎症因子 凝血功能 血液流变学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]