钛网应用于即刻种植骨缺损骨再生的实验研究  

The experimental study of titanium mesh applied to bone regeneration in immediate implant bone defect

作　　者：王晨辰[1] 刘向辉[1] 孙卫革[1] 尹伟[1] 程义成[1] 张磊[1] 

机构地区：[1]安徽医科大学解放军八一临床学院口腔科,南京210002

出　　处：《安徽医科大学学报》2017年第6期814-818,共5页Acta Universitatis Medicinalis Anhui

基　　金：2014年度南京军区医学科技创新课题面上项目(编号:14MS045)

摘　　要：目的通过动物实验观察钛网联合引导骨组织再生技术(GBR)在不同植体即刻种植周围骨缺损骨再生过程中的实际成骨效果。方法 6只成年健康比格犬,拔除双侧下颌2、3、4前磨牙,一侧植入韩国DIO植体4枚,另一侧植入ITI植体4枚。每颗植体周围制作垂直-水平联合型骨缺损,48枚植体按照处理方法不同分为4组:对照组、GBR组、钛网+骨粉组、钛网+GBR组。6个月后处死实验犬,通过直观测量、硬组织切片和新生骨形成率比较各组骨再生效果。结果酸蚀喷砂(SLA)表面的植体周围骨再生各项指标均明显优于可吸收研磨介质(RBM)表面;组间相比差异均有统计学意义(P<0.05),钛网+GBR组骨再生效果最佳,GBR组和钛网+骨粉组次之,对照组最差,其中GBR组和钛网+骨粉组差异无统计学意义。结论 SLA表面处理方法有利于即刻种植周围骨缺损的骨整合;钛网联合GBR技术作为一种即刻种植周围骨缺损骨再生的新方法,效果稳定可靠。Objective To observe the effect of titanium mesh combined with guided bone regeneration technique （GBR） technique in the bone regeneration of immediate implantation of bone defect around titanium mesh. Meth- ods 6 healthy adult beagle dogs were 2, 3, 4 mandibular premolars, DIO implant was implanted into one side of South Korea 4, the other side of the implantation of ITI implants 4. Each implant makingcombined vertical horizon- tal bone defect, 48 implants according to the differenttreatment methods were divided into four groups： control group, GBR group, titanium mesh bone and titanium mesh group ＋ GBR group. After 6 months, the experimental dogs were sacrificed and the effect of bone regeneration was compared between the two groups by visual measure- ment, hard tissue section and new bone formation rate. Results Sandblasting etching（SLA） peri implant bone re- generation indicators were significantly better than the absorption of grinding medium surface treatment group （RBM） surface treatment group ; group compared to find differences between the groups were statistically significant （ P 〈 0.05 ） , titanium mesh group ＋ GBR bone regeneration effect is the best, GBR group and titanium mesh bone meal ＋ group the control group is the worst, there was no significant difference between GBR group and titanium mesh ＋ bone meal group. Conclusion The SLA surface treatment method is beneficial to the immediate implanta- tion of bone defect around bone; titanium mesh combined with GBR technology as a new method of immediate im- plantation of bone defect around bone defect, the effect is stable and reliable.

关 键 词：钛网 即刻种植 垂直-水平联合型骨缺损 引导骨组织再生技术 

分 类 号：R782.1[医药卫生—口腔医学]