放疗联合p53腺病毒治疗中晚期宫颈癌近期疗效分析  

Short-term efficacy of radiotherapy combined with p53 adenovirus in the treatment of advanced cervical cancer

作　　者：张冬娟[1] 杨林[1] 陈象逊[1] 汪浩[1] 

机构地区：[1]安徽医科大学第一附属医院肿瘤放疗科,合肥230022

出　　处：《安徽医科大学学报》2017年第6期874-878,共5页Acta Universitatis Medicinalis Anhui

基　　金：安徽省卫生计生委中医药科研课题(编号:2016zy33)

摘　　要：目的评价调强放疗联合重组人p53腺病毒注射液治疗中晚期宫颈癌的近期临床疗效。方法 46例中晚期宫颈癌患者随机分为治疗组(调强放疗联合p53基因治疗)21例和对照组(单纯调强放疗)25例。治疗组给予重组人p53腺病毒注射液瘤内注射每周1次,两组患者放疗剂量和放疗方法相同,治疗结束2个月后,复查评估治疗疗效;并于放疗前后刷取宫颈细胞,行DNA倍体定量分析,比较两组患者宫颈细胞DNA指数≥2.5的细胞个数。结果治疗组完全缓解(CR)13例(61.9%),部分缓解(PR)6例(28.6%),有效率90.5%;对照组CR 7例(28%),PR 9例(36%),有效率64.0%;治疗组有效率明显高于对照组(P<0.05)。DNA倍体定量分析放疗后治疗组与对照组差异有统计学意义(χ~2=4.544,P=0.033)。结论影像学及DNA倍体定量分析结论一致,提示重组人p53腺病毒联合调强放疗治疗中晚期宫颈癌近期疗效优于单独放疗组。Objective bined with recombinant To evaluate the recent clinical effects of intensity modulated radiation therapy（IMRT） com- human p53 adenovirus injection in the treatment of locally advanced cervical cancer. Meth- Forty-six patients diagnosed with locally advanced cervical carcinoma were divided randomly into the treat-ment group（IMRT combined with p53 gendicine injection） and the control group（ single IMRT） ,with 21 cases in the former group and 25 cases in the other group. Recombinant human p53 adenovirus intratumor injection was per- formed once a week. The radiotherapy dose and radiotherapy regimen were the same for both groups. After two months of treatment, the efficacy of the treatment was evaluated and the cervical cells were brushed before and after radiotherapy. The number of cells in the cervical cell DNA index≥2.5 was compared between the two groups. Re- salts In the treatment group,complete remission（CR） was in 13 patients（61.9% ） ;partial remission（PR） 6 pa- tients （28.6%）, and the effective rate was 90. 5 % ;in the control group, C R was in 7patients （28 % ）, PR 9 patient （36%） ,and the effectiverate was 64%. The effective rate of treatment group was higher than that of the control group（90. 5% vs 64.0% ;P 〈 0. 05 ）. Analysis of DNA ploidy quantitative after radiotherapy in treatment group and control group was statistically significant（ X2 = 4. 544 ,P =0. 033 ）. Conclusion Imaging and DNA ploidy quantita- tive analysis conclusion is consistent and showed that recombinant human adenovirus p53 combined with IMRT in the treatment of advanced cervical cancer recent curative effect is better than single IMRT.

关 键 词：宫颈癌 调强放疗 重组人P53腺病毒注射液 

分 类 号：R73[医药卫生—肿瘤]