复方苦参注射液和芬太尼透皮贴剂联合治疗老年晚期胃癌癌性疼痛的疗效  

Therapeutic efficacy of compound matrine injection combined with Fentanyl transdermal patch on cancer pain in elderly patients with advanced gastric cancer

作　　者：王静[1] 陶熔[1] 吴广银[2] 夏令杰[1] 

机构地区：[1]河南省人民医院疼痛科,郑州450003 [2]郑州河南省人民医院放疗科,450003

出　　处：《中华老年医学杂志》2017年第6期677-679,共3页Chinese Journal of Geriatrics

摘　　要：目的评估复方苦参注射液和芬太尼透皮贴剂联合治疗老年晚期胃癌癌性疼痛患者的临床疗效。方法老年晚期胃癌患者100例随机分为观察组（50例），给予复方苦参注射液联合芬太尼贴剂治疗；对照组（50例），单独使用芬太尼贴剂治疗，比较两组的止痛效果，生活质量改善情况和不良反应。结果观察组止痛有效率为76％（38／50）明显高于对照组56％（28／50）（χ^2=4．46，P〈0．05）。治疗后两组生活质量评分均较治疗前明显改善，而且观察组生活质量评分明显高于对照组[（46．1±2．4）分和（33．9±1．9）分，t=8．61，P〈0．05）]。两组治疗后仅出现轻微的不良反应，其不良反应发生率均为16％（8／50），二组比较差异无统计学意义（χ^2=0．00，P〉0．05）。结论复方苦参注射液联合芬太尼贴剂治疗老年晚期胃癌癌性疼痛效果显著，安全性高。Objective To evaluate the clinical efficacy of compound matrine injection combined with fentanyl transdermal patch in the treatment of elderly patients with advanced gastric cancer. Methods A total of 100 elderly patients with advanced gastric cancer were enrolled in this study. All patients were randomly divided into the observation group（n= 50）given compound matrine injection plus Fentanyl transdermal patch and the control group given fentanyl transdermal patch alone（n=50）. The analgesic efficacy, quality of life and adverse reaction were evaluated and compared between the two groups. Results The analgesic efficacy was significantly higher in the observation group[76% （38/50）]than in the control group[（44%）, （χ^2 = 4.46,P〈0.05）]. Before treatment, the life quality scores were similar between two groups. After treatment, the life quality score of the two groups was significantly improved as compared with pre-treatment. In addition, life quality score was significantly higher in the observation group than in control group（t=8.61, P〈0.05）. After treatment, only mild adverse events were observed in two groups, with no significant difference in adverse events between the two groups （ χ^2 = 0.00, P 〉 0.05 ）. Conclusions Compound matrine injection plus Fentanyl transdermal patch are safe and effective in the treatment of carcinoma pain in elderly patients with advanced gastric cancer.

关 键 词：苦参 芬太尼 晚期胃癌 癌性疼痛 

分 类 号：R735.2[医药卫生—肿瘤]