痴呆伴发精神行为症状的临床研究  

Clinical research of dementia with behavioral and psychological symptoms

作　　者：沐楠[1,2] 饶冬萍[2] 张若曦[2] 唐牟尼[2] 郁俊昌[2] 陈建平[2] 潘集阳[1] 

机构地区：[1]暨南大学第一临床医学院,广州市510632 [2]广州市脑科医院,510370

出　　处：《实用医学杂志》2017年第10期1612-1615,共4页The Journal of Practical Medicine

基　　金：广东省自然科学基金资助项目(编号:8151037001000006)

摘　　要：目的:探讨痴呆伴发精神行为症状的临床特点以及不同亚综合征与认知的关系。方法:采用神经精神科问卷、简易智力检测量表(MMSE)评估116例符合美国精神病协会精神障碍诊断与统计手册第4版修订版(DSM-IV-R)痴呆诊断标准的患者。因子分析采用主成分因子提取法,并对因子负荷进行正交方差极大旋转。结果:因子分析获得5个亚综合征,分别为脱抑制行为、精神病性、激越、情感、淡漠因子。MMSE总分、教育年限进入了淡漠因子的回归方程(P<0.05)。结论:痴呆伴发精神行为症状可以划分为5个临床亚综合征,其中淡漠因子与认知功能相关。Objective To discuss the clinical features of behavioral and psychological symptoms of dementia （BPSD） and the relation between different sub-clinical syndromes and cognition. Methods One hundred and sixteen dementia patients were assessed with neuropsychiatrie inventory and mini- mental state examination （MMSE） and made factor analysis according to DSM-IV-R. Results Twelve common behavioral and psychological symptoms could be further divided into five sub-syndromes, including disinhibition behavior, psychosis, agitation, emotion and apathy factors. MMSE total score and years of education entered regression equation of apathy factor （P〈0.05）. Conclusion BPSD can be divided into five factors and apathy factor are related with cognitive function.

关 键 词：行为症状 痴呆 因素分析 淡漠 

分 类 号：R749.16[医药卫生—神经病学与精神病学]