甲状腺微小乳头状癌中央组淋巴结转移与临床病理特征的关系  

Relationship between central lymph node metastasis and clinical features of papillary thyroid microcarcinoma

作　　者：李威威[1] 王林[1] 曾理[1] 李健勇[1] Li Weiwei Wang Lin Zeng Li Li Jianyong(Department of Oncology, the First People＇s Hospital of Tianmen City, Tianmen 431700, China)

机构地区：[1]湖北省天门市第一人民医院肿瘤科,431700

出　　处：《肿瘤研究与临床》2017年第5期327-330,共4页Cancer Research and Clinic

摘　　要：目的 分析甲状腺微小乳头状癌中央组淋巴结转移与临床病理特征的关系.方法 2010年1月至2016年10月行甲状腺微小乳头状癌手术并中央组淋巴结清扫患者137例,其中男性35例,女性102例;年龄≤45岁49例,〉45岁88例;肿瘤直径≤5 mm 36例,〉5 mm 101例;肿瘤区纤维化72例,无纤维化65例;沙砾体22例,无沙砾体115例;肿瘤伴发慢性淋巴细胞性甲状腺炎16例,无伴发121例.采用χ2检验分析影响中央组淋巴结转移的临床因素.结果 137例患者中央组淋巴结转移者52例（38.0%）.年龄、肿瘤直径、纤维化、沙砾体与中央组淋巴结转移有关（χ2值分别为4.48、5.60、7.30、7.30,均P〈0.05）.性别、肿瘤伴发慢性淋巴细胞性甲状腺炎与中央组淋巴结转移无关（均P〉0.05）.结论 年龄≤45岁、肿瘤直径〉5 mm、肿瘤区域出现纤维化、沙砾体与甲状腺微小乳头状癌中央组淋巴结转移高风险有相关性.Objective To analyze the relationship between central lymph node metastasis and clinical features of papillary thyroid microcarcinoma. Methods From January 2010 to October 2016, 137 patients were treated with papillary thyroid microcarcinoma and central lymph node dissection. Among them, 35 were male and 102 were female. There were 49 cases with age ≤ 45 years old, 88 cases 〉 45 years old. 36 cases had diameter of tumor≤5 mm, 101 cases〉5 mm; There were 72 cases with tumor fibrosis, 65 cases without fibrosis; 22 cases with psammoma bodies, 115 cases without psammoma bodies. There were 16 cases with tumor associated with chronic lymphocytic thyroiditis, 121 cases without them. The clinical factors affecting lymph node metastasis in the central group were analyzed byχ2 test. Results Of the 137 patients, 52 cases （38.0%） had central lymph node metastasis. Age, tumor diameter, fibrosis, psammoma bodies had relationship with central lymph node metastasis （χ2 values were 4.48, 5.60, 7.30, 7.30, all P〈0.05）. Sex, tumor associated with chronic lymphocytic thyroiditis had no relationship with central lymph node metastasis （all P〉 0.05）. Conclusion The papillary thyroid microcarcinoma patients with age≤45 years old, tumor diameter〉5 mm, fibrosis in the tumor area and psammoma bodies have high risk of lymph node metastasis.

关 键 词：甲状腺肿瘤 癌 乳头状 冷冻切片 病理状态 体征和症状 淋巴转移 

分 类 号：R736.1[医药卫生—肿瘤]