小肠原发性绒毛膜癌临床病理分析并文献复习  

Clinicopathologic analysis of primary small intestinal choriocarcinoma and review of literature

作　　者：王超[1] 范新娟[1] 黄艳[1] 

机构地区：[1]中山大学附属第六医院病理科,广州510655

出　　处：《临床与病理杂志》2017年第5期943-947,共5页Journal of Clinical and Pathological Research

基　　金：国家自然科学基金(81572371)~~

摘　　要：目的:探讨小肠原发性绒毛膜癌的临床特征、病理特点、诊断及治疗方法。方法:分析8例小肠原发性绒癌的临床病理特征,复习相关文献。结果:8例病例的典型症状为黑便,5例病变部位位于空肠。所有病例血清β-hCG均异常升高。主要病理特点为细胞滋养细胞及合体滋养细胞呈片状分布,伴出血及坏死。免疫组织化学结果示肿瘤细胞β-hCG为阳性。结论:小肠原发性绒毛膜癌十分罕见,但仍应纳入鉴别诊断。通过形态学特点、免疫表型及检测血清β-hCG水平可确诊。Objective： To explore the clinical feature, pathological characteristic, diagnosis and treatment of primary small intestinal choriocarcinoma. Methods： The clinicopathological features of 8 cases of primary small intestinal choriocarcinoma were analyzed and relevant literature were reviewed. Results： Among the 8 cases, the characteristic symptom was melena, and 5 of them were originated from jejunum. An elevated serum β-hCG level was detected in all cases. Microscopically, the tumor consists of cytotrophoblasts and syncytiotrophoblasts, associated with hemorrhage and necrosis. Immunohistochemically, the tumor cells were positive for β-hCG. Conclusion： Although primary small intestinal choriocarcinoma is rare, it should be considered as one of the differential diagnoses. Morphological features, immunohistochemical characteristics and measurement of serum β-hCG level could be used to confirm the diagnosis.

关 键 词：绒毛膜癌 小肠 诊断 免疫组织化学 

分 类 号：R735.32[医药卫生—肿瘤]