影响原发性肝癌患者手术治疗预后的危险因素分析  

Analysis of the risk factors for prognosis of surgical treatment patients with primary liver cancer

作　　者：孙志德[1] 程利民[1] 平萍[1] 刘金龙[1] 张学军[1] 郝彦广 李巍[1] 

机构地区：[1]承德医学院附属医院外一科,河北承德067000 [2]河北省围场满族蒙古族自治县中医院普外科,河北围场068450

出　　处：《临床和实验医学杂志》2017年第12期1204-1207,共4页Journal of Clinical and Experimental Medicine

基　　金：河北省承德市科技支撑计划项目(编号20151033)

摘　　要：目的分析影响原发性肝癌手术治疗预后的危险因素。方法回顾性分析因原发性肝癌行肝切除的109例患者的临床资料,以5年生存率为指标,观察影响原发性肝癌手术治疗预后的危险因素。结果肿瘤直径>5 cm、术前甲胎蛋白(AFP)>400μg/L、术前术后AFP动态变化、肿瘤合并肝硬化、肿瘤侵及血管、术后未行预防性肝动脉化疗栓塞(TACE)辅助治疗均为影响肝癌术后生存率的独立危险因素(P<0.05)。结论影响原发性肝癌手术治疗预后的危险因素较多,肝癌患者肿瘤较大、合并肝硬化、肿瘤血管侵犯、手术前后AFP动态变化多预示患者术后预后不良,术后及时预防性TACE可改善患者预后。Objective To analyze 出 e risk factors for prognosis of surgical treatment of primary hepatocellular carcinoma （PHC ）. Meth-ods The clinical data of 109 patients who underwent hepatectomy for PHC in our hospital were retrospectively analyzed. The 5 - year survival rate was used as the observation index to observe the risk factors of the prognosis of PHC. Results Tumor diameter 〉 5 cm, AFP 〉 400 μg/ L , chan-ges of preoperative and postoperative AFP, combined with cirrhosis, tumor invasion of blood vessels, postoperative adjuvant therapy with TACE were the independent factors which affected the survival rate of hepatocellular carcinoma （ P 〈 0. 0 5 ） . Conclusion There are many factors which will affect the prognosis of primary hepatocellular carcinoma （PHC）. Patients with large tumor, combined with cirrhosis, tumor invasion of blood vessels, changes of preoperative and postoperative AFP, AFP 〉 400 μg/L can predict the poor prognosis of patients after surgery, prophylactic postoperative TACE can improve the prognosis of patients.

关 键 词：原发性肝癌 手术治疗 5年生存率 危险因素 

分 类 号：R735.7[医药卫生—肿瘤]