视黄醛脱氢酶1在胆囊癌中的表达及其临床意义  

Expression and clinical significance of retinal dehydrogenase 1(ALDH1A1) in gallbladder carcinoma by tissue microarray

作　　者：黄海林[1] 陈超[1] 甘泉[1] 杜哲明[1] HUANG Hailin CHEN Chao GAN Quan and DU Zheming.(Department of General Surgery, Hospital of Jiangxi Provincial Corps, China People＇ s Armed Police Force, Nanchang 330030, Chin)

机构地区：[1]武警江西总队医院外一科,南昌330030

出　　处：《武警医学》2017年第4期337-339,343,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的观察视黄醛脱氢酶1(retinal dehydrogenase 1,ALDH1A1)在胆囊癌组织中的表达及其临床意义。方法采用组织芯片技术和免疫组织化学方法检测59例胆囊癌组织标本,7例癌旁组织标本及6例慢性胆囊炎组织标本中ALDH1A1表达情况。结果 ALDH1A1在6例慢性胆囊炎和7例癌旁组织中全部阳性表达,在59例胆囊癌组织中,ALDH1A1表达率为62.7%(37/59),慢性胆囊炎、癌旁组织与胆囊癌组织中ALDH1A1表达差异有统计学意义(P<0.05)。ALDH1A1与疾病进展和组织分化呈负相关,表达差异有统计学意义(P<0.05)。结论胆囊癌组织中ALDH1A1蛋白的表达与疾病进展和组织分化呈负相关。Objective To explore the expression and clinical significance of retinal dehydrogenase 1 （ALDH1A1） in gallblad- der carcinoma. Methods The expressions of ALDH1 A1 were detected in 59 specimens of gallbladder carcinoma tissues ,7 specimens of adjacent non-tumor tissues and 6 specimens of chronic cholecystitis tissues by tissue microarray technique and immunohistochemistry. Results In 7 specimens of adjacent non-tumor tissues and 6 specimens of chronic cholecystitis tissues, there was a positive expression of ALDH1A1. The expression of ALDH1A1 was not detected or weakly positive in 59 gallbladder carcinoma tissue specimens and the positive rate was 62.7% （37/59）. The positive rate of ALDH1 A1 in tissue specimens of gallbladder carcinoma was significantly lower than the expression in the adjacent non-tumor tissues or chronic cholecystitis tissues（ P 〈 0.05 ）. ALDH1A1 was negatively correlated with disease progression and tissue differentiation, and there was significant difference in levels of expression （P 〈 0. 05 ）. Conclusions The expression of ALDH1 A1 in gallbladder carcinoma tissues is negatively correlated with the progression of disease and tissue differentiation.

关 键 词：胆囊癌 组织芯片技术 视黄醛脱氢酶1 

分 类 号：R735.8[医药卫生—肿瘤]