S100A8在非小细胞肺癌中的表达及其临床意义  

Expression of S100A8 in non-small cell lung cancer and its clinical significance

作　　者：吕彦天[1] 阮婷[1] 徐国鹏[1] 

机构地区：[1]南京医科大学附属苏州医院,江苏苏州215002

出　　处：《临床肺科杂志》2017年第7期1201-1204,共4页Journal of Clinical Pulmonary Medicine

基　　金：南京医科大学科技发展基金面上项目(No 2014NJ MU105)

摘　　要：目的探讨非小细胞肺癌(non-small cell lung cancer,NSCLC)中S100A8基因的表达以及其与NSCLC患者临床病理特点之间的关系。方法以免疫组织化学方法检测96例NSCLC及35例癌旁肺组织中S100A8蛋白的表达,并分析其与临床病理特点之间的关系。结果免疫组化结果显示,S100A8在肿瘤组织中的水平显著高于癌旁组织(P<0.05)。在TNM分期较晚的患者中S100A8表达显著增高(P<0.05)。高分化NSCLC中S100A8表达水平显著低于中低分化NSCLC(P<0.05)。结论 S100A8蛋白表达在NSCLC组织中明显高于癌旁肺组织,随病理分期增高及肿瘤分化程度减低,S100A8蛋白表达阳性率增高,提示S100A8蛋白与NSCLC的关系密切相关。Objective To investigate the expression of S100A8 gene in non small cell lung cancer（ NSCLC） and the relationship between the expression of S100A8 and clinicopathological features of patients with NSCLC. Methods The expression of S100A8 protein in 96 cases of NSCLC and 35 cases of corresponding para-carcinoma tissue were detected by immunohistochemistry, and the relationship between the expression of S100A8 protein and clinicopathological features was analyzed. Results The immunohistochemical results showed that the level of S100A8 in tumor tissues were significantly higher than that in para-carcinoma tissue （P 〈0. 05）. The expression of S100A8 was significantly higher in patients at late TNM stage （ P 〈 0. 05 ）. The expression level of S100A8 in the highly differenti-ated NSCLC was significantly lower than that in the low and middle differentiated NSCLC （P 〈0. 05）. Conclusion The expression of S100A8 protein in NSCLC tissues is significantly higher than that in para-carcinoma tissue. The positive rate of S100A8 protein expression increases with the late stage of pathology and poor tumor differentiation, which indicates that the S100A8 protein is closely related with NSCLC.

关 键 词：非小细胞肺癌 S100A8 免疫组织化学 

分 类 号：R734.2[医药卫生—肿瘤]