人类疱疹病毒6型的再激活及其临床意义  

Reactivation of human herpesvirus 6 and its clinical significance

作　　者：吴克复[1] 郑国光[1] 马小彤[1] 宋玉华[1] 

机构地区：[1]中国医学科学院 北京协和医学院 血液学研究所 血液病医院 实验血液学国家重点实验室,天津300020

出　　处：《白血病．淋巴瘤》2017年第5期257-260,共4页Journal of Leukemia & Lymphoma

基　　金：国家自然科学基金（81370634、81570153、81670158、81470278）

摘　　要：人类疱疹病毒6型（HHV-6）是人群中普遍存在、体内广泛传播的双链DNA病毒.该病毒能终身隐性感染,免疫低下时再激活可以导致严重疾病,具有潜在的危害性.近年来造血干细胞移植治疗得到广泛应用,脑炎等移植并发症与HHV-6再激活相关.在约1%的感染人群中,HHV-6与染色体端粒整合,能纵向传递,呈内源性持续感染状态,是导致活动性病毒感染的内源性因素.随着检测方法的进步,临床研究资料揭示了HHV-6再激活与一些疾病的关系,尤其与淋巴瘤、白血病和一些造血和免疫系统慢性疾病的关系,受到关注.Human herpesvirus 6 （HHV-6） is recognized as a ubiquitous dsDNA virus in human with widespread cell tropism in vivo, which could induce lifelong latent infection and be reactivated in some immunocompromised individuals leading to serious diseases. With the increasing application of hematopoietic stem cell transplantation （HSCT）, it is obvious that HHV-6 reactivation has a close relationship with several complications including encephalitis after transplantation. On the other hand, among about 1 % infected people, HHV-6 and subtelomeric region of cell chromosomes in the state of endogenous persistent infection play a part in activated virus infection. As the detection methods make a great progress in HHV-6 detection, clinical data reveals the relationship between HHV-6 reactivation and lots of chronic diseases, especially lymphoma, leukemia as well as some chronic hematopoietic and immunological diseases.

关 键 词：疱疹病毒6型 人 造血干细胞移植 淋巴瘤 白血病 

分 类 号：R733[医药卫生—肿瘤]