短暂性脑缺血发作对卒中后脑保护的临床观察  

Clinical observation of transient cerebral ischemic attack on cerebral protection after stroke

作　　者：曲延民[1] 李晓林[2] 

机构地区：[1]哈尔滨市第一医院神经内科,黑龙江哈尔滨150001 [2]黑龙江省医院,黑龙江哈尔滨150001

出　　处：《中风与神经疾病杂志》2017年第5期428-431,共4页Journal of Apoplexy and Nervous Diseases

摘　　要：目的比较短暂性脑缺血发作(TIA)后卒中与无TIA发作脑卒中患者临床预后,探讨体内缺血预适应对脑组织保护机制;方法选择首次急性脑卒中住院患者340例,按有无TIA发作分为TIA组和无TIA组,观察患者神经功能改善情况及再梗死率,并分析日常生活活动能力恢复程度;结果与无TIA发作组比较,既往有与此次脑梗死相关TIA组患者临床症状明显改善;结论 TIA作为体内缺血预适应可诱导一系列内源性保护机制减少脑组织损伤。Objective To compare the protective effect of ischemic preconditioning on brain tissue in patients with transient ischemic attack（ TIA） and stroke without TIA;Methods 340 patients with first acute stroke were divided into TIA group and uon-TIA group according to the presence or absence of TIA. The improvement of neurological function and rein- farction rate were observed and the degree of recovery of daily living activity was analyzed;Results Compared with the non-TIA attack group, there was a significant improvement in the clinical symptoms of TIA patients associated with this cere- bral infarction ; Conclusion TIA as an in vivo ischemie preconditioning can induce a series of endogenous protective mech- anisms to reduce brain tissue damage.

关 键 词：短暂性脑缺血发作 脑卒中 缺血预适应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]