视网膜静脉阻塞的危险因素分析  

Risk factors associated with retinal vein occlusion

作　　者：胡一骏[1,2] 李冬莉[1] 李国栋[3] 蔡斌[1] 耿宇[1] 李建华[1] 陆莉[1] 袁玲[1] 

机构地区：[1]昆明医科大学第一附属医院眼科,云南省昆明市650032 [2]汕尾亮睛工程眼科医院眼科,广东省汕尾市516600 [3]南昌大学第二附属医院眼科,江西省南昌市330006

出　　处：《眼科新进展》2017年第6期544-547,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金(编号:81260151);云南省应用基础研究计划项目(编号:2016FB126);云南省科技厅科技惠民计划项目(编号:2014RA009)~~

摘　　要：目的分析视网膜中央静脉阻塞(central retinal vein occlusion,CRVO)和视网膜分支静脉阻塞(branch retinal vein occlusion,BRVO)的危险因素;并对CRVO和BRVO危险因素进行直接比较。方法对46例CRVO(CRVO组)、33例BRVO(BRVO组)与79例老年性白内障或屈光不正患者(对照组)行危险因素和血脂谱分析,并对比观察。结果多元线性回归分析结果显示:高同型半胱氨酸血症(P<0.000 1)、高总胆固醇(P=0.003 0)、高脂蛋白a(P=0.027 0)、高血压(P=0.022 0)、短眼轴(P<0.000 1)与CRVO显著相关;而高同型半胱氨酸血症(P<0.000 1)、高总胆固醇(P=0.008 0)、高血压(P=0.002 0)、高体质量指数(P=0.004 0)、短眼轴(P=0.001 0)与BRVO相关。一元线性回归分析示CRVO和BRVO上述危险因素比较没有明显差别。结论 CRVO、BRVO危险因素包括系统(高血脂、高血压、高同型半胱氨酸)和眼部(短眼轴)的多种因素,但是这些危险因素在CRVO和BRVO之间没有显著差异。Objective To perform a risk factor analysis of central retinal vein oc- clusion （CRVO） and branch retinal vein occlusion （ BRVO）, and compare the difference in risk factors between CRVO and BRVO. Methods Retrospective observational case- control study included 46 CRVO patients,33 BRVO patients and 79 control subjects with senile cataract or refractive error, the risk factors and blood lipid spectrum analysis were performed and compared. Results Multivariate linear regression analysis showed that higher serum levels of homocysteine （P 〈 0. 000 1 ）, total cholesterol （ P = 0.003 0）, lipoprotein （a） （P = 0.027 0 ）, hypertension （ P = 0. 022 0 ） and shorter axial length （P 〈 0.000 1 ） were significantly correlated with CRVO. BRVO was associated with higher serum levels of homocysteine （P 〈 0. 000 1 ） ,total cholesterol （P = 0. 008 0 ）, hyper- tension （P = 0. 002 0） , body mass index （P = 0. 004 0） and shorter axial length （ P = 0. 001 0）. There was no significant difference in risk factors between CRVO and BRVO patients on multivariate analysis. Conclusion Multiple systemic （ hyperlipidemia, hy- pertension and hyperhomocystinemia） and ocular （ shorter axial length） risk factors are associated with both CRVO and BRVO, but these risk factors are not different between CRVO and BRVO.

关 键 词：视网膜中央静脉阻塞 视网膜分支静脉阻塞 危险因素 

分 类 号：R774.1[医药卫生—眼科]