诱导多能干细胞在视网膜疾病研究中的应用  

Application of induced pluripotent stem cells in retinal diseases

作　　者：王松涛[1,2] 周国民[2] 

机构地区：[1]新乡医学院人体解剖学教研室,河南省新乡市453003 [2]复旦大学上海医学院人体解剖与组织胚胎学系,上海市200032

出　　处：《眼科新进展》2017年第6期587-590,共4页Recent Advances in Ophthalmology

基　　金：国家自然科学基金资助(编号:81170885);新乡医学院博士科研基金资助(编号:XYBSKYZZ2015010-505119)~~

摘　　要：诱导多能干细胞(induced pluripotent stem cells,iPSCs)是成体细胞通过重编程而获得的一类具有胚胎干细胞相似特性和功能的细胞。近年来,iPSCs在再生医学和干细胞研究领域备受关注,尤其是患者特异源性iPSCs,来源方便、无免疫排斥和伦理学问题,同时还可以保留特定个体基因型,为再生医学以及细胞移植疗法提供了新的细胞来源。目前,iPSCs在视网膜疾病研究领域取得了长足的进步。本文主要对iPSCs向视网膜色素上皮细胞、感光细胞和神经节细胞的诱导分化及细胞移植研究、安全性评价等方面进行综述,探讨iPSCs在视网膜疾病研究中的应用和前景。Induced pluripotent stem cells （iPSCs） are a type of pluripotent stem cells that can be generated from adult somatic cells. They have similar characteristics and function to embryonic stem cells （ESCs）. Over the past decade, iPSCs were widely concerned in regenerative medicine and stem cell field. Especially the patient specific iPSCs have several advantages over ESCs, such as convenient source, do not exist im- mune rejection and ethical issues, even keep certain individual genotype. At present, tre- mendous progress have been made about the application of iPSCs in a variety of retinal diseases. Here, this article reviews pluripotent stem cell sources of RPE,photoreceptors and retinal ganglion cells and current transplantation strategies, the safety problems and prospects.

关 键 词：诱导多能干细胞 视网膜疾病 再生医学 细胞移植 

分 类 号：R774[医药卫生—眼科]