关注线粒体老化在缺血性脑损害中的作用  

Focus on role of mitochondrial aging in the cerebral ischemia

作　　者：王庆松[1] 何婧[1,2] 

机构地区：[1]成都军区总医院神经内科,四川成都610000 [2]西南医科大学,四川泸州64600

出　　处：《西部医学》2017年第6期741-744,748,共5页Medical Journal of West China

基　　金：四川省卫计委科学研究项目(150002;16PJ014)

摘　　要：随着人口老龄化进程的不断加速,脑血管疾病的发病率快速增长,增龄性相关线粒体老化在神经系统疾病中的作用越来越受到关注。生理性线粒体老化是缺血性脑损伤的重要机制之一,而脑缺血又可加速病理性线粒体老化的进程,二者相互促进,形成恶性循环,对缺血性脑损害及其相关卒中后认知功能受损可能具有重要意义。因此,本文针对缺血性脑损害线粒体老化现象,揭示可能的脑血管病相关致病机制和探寻卒中防治策略提供新思路。With the acceleration of population ageing process, the rapid growth of the disease burden of cerebro- vascular disease. Mitochondria in aging-related aging in recent years in diseases of the nervous system get more and more attention. Physiological mitochondrial aging is one of important mechanism about ischemic brain damage, and ischemic brain damage can accelerate process of pathological mitochondrial aging. Ischemia and mitochondrial aging promote each other, creating a vicious circle, which may has important meaning in ischemic brain damage and the post stroke cognitive impairment. So, if further discuss related mechanism may on reveals brain vascular disease related pathogenic mechanism, and explore new idea for stroke prevention technology.

关 键 词：线粒体老化 脑缺血 脑血管疾病 

分 类 号：R743[医药卫生—神经病学与精神病学]