胃癌D2根治术中纳米碳显影法应用研究  

Application of nanometer carbon development in D2 radical operation of gastric cancer

作　　者：赵玉洲[1] 韩广森[1] 顾焱晖[1] 马鹏飞[1] 刘晨宇[1] 霍明科 曹养辉[1] 张俊立[1] 

机构地区：[1]河南省肿瘤医院普外科,河南郑州450000

出　　处：《中华肿瘤防治杂志》2017年第7期477-480,共4页Chinese Journal of Cancer Prevention and Treatment

基　　金：河南省科技攻关项目(201403214)

摘　　要：目的目前认为进展期胃癌分检35枚淋巴结更贴合患者准确病理分期,但常规分检淋巴结方法很难实现。本研究探讨纳米碳显影法在胃癌D2根治术中淋巴结分检中的应用优势。方法回顾性分析2015-10-01-2016-09-30河南省肿瘤医院普外科100例胃癌患者临床资料,按是否应用纳米碳显影分为纳米碳显影组(观察组)和非显影组(对照组),对照2组检出淋巴结总数、平均检出淋巴结数、淋巴结<15枚例数、阳性淋巴结数、淋巴结阳性率、患者转移率、平均直径<5mm数、平均直径<5mm阳性淋巴结数、第1、2站淋巴结数和淋巴结分检时间等指标。结果观察组检出淋巴结总数(3 005枚)和阳性淋巴结总数(509枚)均高于对照组的1 560和305枚。观察组和对照组平均检出淋巴结数分别为62.943±14.507和32.436±5.743,差异有统计学意义,P<0.001;淋巴结分检时间分别为(14.1±2.5)和(17.4±3.2)min,差异有统计学意义,P<0.001;平均直径<5mm数分别为28.972±7.819和9.503±3.390,差异有统计学意义,P<0.001;平均直径<5mm阳性淋巴结分别为17.065±7.610和11.124±8.376,差异有统计学意义,P=0.010;第1(36.605±12.720和19.391±4.518)和第2站淋巴结数(30.110±10.298和14.876±5.396)差异统计学意义,P<0.001;淋巴结阳性率分别为(0.461±0.249)%和(0.453±0.272)%,差异无统计学意义,P=0.948。结论采用纳米碳显影方法在胃癌D2根治术的淋巴结分检中具有操作简便,获取淋巴结数目多,更有利于准确病理分期等优点。OBJECTIVE It is considered that 35 lymph nodes of the patients with advanced gastric cancer are more suitable for patients with accurate pathological stage at present, but it is difficult to realize using the routine method, the article aiming to introduce the application of nanometer carbon development in D2 radical operation of gastric cancer. To explore the technical advantages of nanometer carbon development in D2 radical operation of gastric cancer. METHODS From Oct. 2015 to Sep. 2016, 100 patients with gastric cancer in general surgery department of Henan pro- vincial tumor hospital were randomly divided into two groups according to whether using the nanometer carbon development method or not. The total and average detection number of the lymph node, the inspection number less than 15, pos- itive lymph node number, percentage of positive number, the diameter less than 5mm, diameter less than 5 mm of posi- tive ones, the detection time and the number of the first and second station were compared. RESULTS The total number of lymph node and the positive ones in observation group were higher than that in control group（3 005 vs 1 560,509 vs 305）, the average detection number of the lymph node （62. 943±14. 507 vs 32. 436±5. 743, P=0. 000）, the inspection time （14.1±2.5 vs 17.4±3.2,P=0. 000）, the number of the diameter less than 5 mm （28. 972±7. 819 vs 9. 503±3. 390, P=0. 000）, the diameter less than 5 mm of positive ones （17. 065±7. 610 vs 11. 124±8. 376, P=0. 010） and the number of the first and second station were significantly different （36. 605 ± 12. 720 vs 19. 391 ± 4. 518, P=0. 000; 30. 110±4.10. 298 vs 14. 876±5. 396,P=0. 001）. The rate of positive lymph nodes was no significant difference （0. 461± 0. 249 vs 0.453±0. 272, P=0. 948）. CONCLUSION Using the nanometer carbon development method during operation can help to identify lymph nodes and enhance the accuracy of pathological staging in radical operation of gastric cancer.

关 键 词：纳米碳 胃癌 病理 淋巴结分检 

分 类 号：R735.2[医药卫生—肿瘤]