尼莫地平单用及联合多奈哌齐治疗阿尔茨海默症的临床效果研究  

A comparative study of use of nimodipine alone and combined with donepezil in treating Alzheimer's Disease

作　　者：舒少云 杨琪[1] 张厚兴[1] 陈威[1] 

机构地区：[1]湖北省松滋市人民医院神经内科,434200

出　　处：《白求恩医学杂志》2017年第3期283-285,共3页Journal of Bethune Medical Science

摘　　要：目的探讨尼莫地平单用及联合多奈哌齐治疗阿尔茨海默病(AD)的临床疗效及价值。方法选取我院收治的64例AD患者作为研究对象,随机分为两组,其中对照组(32例)单用尼莫地平治疗,治疗组(32例)在对照组的基础上联合多奈哌齐治疗。分别采用AD评估量表认知分量表(ADAS-cog)、简易智能状态检查量表(MMSE)、日常生活活动量表(ADL)以及Blessed-Roth痴呆(B-R)量表评定两组患者治疗前后的认知功能、精神状况、生活活动以及生活自理能力;此外利用心电监测对两组患者进行心率(HR)和P-R间期的比较;并观察两组患者治疗中的不良反应情况。结果两组患者治疗后的ADAS-Cog、MMSE、ADL以及B-R评分较治疗前均有所改善(P<0.05)。治疗后观察组的ADAS-Cog、MMSE、ADL以及B-R评分均显著好于对照组(P<0.05);在心电监测以及不良反应的比较上两组并无显著差异(P>0.05)。结论对AD患者采用尼莫地平联合多奈哌齐治疗,临床疗效显著,安全性高,具有临床推广意义。Objective To investigate the clinical value and curative effect of nimodipine alone and combined with donepezil in treatment of Alzheimer＇ s Disease. Methods Sixty-four cases of Alzheimer＇ s disease patients treated as the research object in our hospital were randomly divided into 2 groups （n = 32, each group）. The control group was given nimodipine treatment and the observation group was treated with donepezil on the basis of the control group. Scale cognitive subscale （ADAS-cog）, Mini Mental State Examina- tion （MMSE） ,activities of daily living scale （ADL） and the Blessed-Roth Dementia （B-R） scale were used to assess the cognitive function, mental status,life ability and self-care ability before and after treatment of two groups. In addition, ECG monitoring was used to compare the heart rate （HR） and P-R interval between the two groups and adverse reactions of the two groups was also observed. Results The ADAS-Cog, MMSE, ADL and B-R scores of the two groups were improved after treatment （P 〈 0. 05）. After treat- ment, the ADAS-Cog, MMSE, ADL and B-R scores of the observation group were significantly better than those of the control group （P 〈 0.05 ） ; There was no significant difference of ECG monitoring and adverse reactions between the two groups （ P 〉 0. 05 ）. Conclusion The use of nimodipine combined with donepezil in treatment of Alzheimer＇s Disease is safe and clinically effective. It is worthy of clin- ical promotion.

关 键 词：阿尔茨海默症 尼莫地平 多奈哌齐 

分 类 号：R749.16[医药卫生—神经病学与精神病学]