原发恶性纵隔生殖细胞瘤的治疗与预后  

Prognosis and treatment of primary mediastinal germ cell carcinoma

作　　者：李均勇[1] 何明敏[1] 邹雪林 肖至兰[3] 丁振宇[1] 

机构地区：[1]四川大学华西医院肿瘤中心胸部肿瘤科四川大学生物治疗国家重点实验室,四川成都610041 [2]成都市第七人民医院呼吸科,四川成都610041 [3]四川大学华西医院胸外科,四川成都610041

出　　处：《现代肿瘤医学》2017年第13期2055-2057,共3页Journal of Modern Oncology

基　　金：国家自然科学基金项目(编号:81272684)

摘　　要：目的:探讨纵隔原发恶性生殖细胞肿瘤的临床特征、治疗及预后。方法:回顾性分析四川大学华西医院2008年至2013年收治的生殖细胞瘤患者,筛选纵隔原发恶性生殖细胞肿瘤,采集临床病理资料分析预后。结果:经病理确诊生殖细胞瘤患者共1 523例,原发于纵隔163例,其中恶性14例,包括精原细胞瘤6例,非精原细胞瘤8例。病人接受手术、放疗及化疗的综合治疗。精原细胞瘤患者生存时间优于非精原细胞瘤患者(P=0.015)。结论:精原细胞瘤患者生存优于非精原细胞瘤患者。手术对纵隔原发恶性GCT的价值仍难以断定,需要仔细评估疾病的具体情况。放化疗的综合治疗应当是此类病人的主要治疗模式。Objective：To investigate the clinical outcome and treatment of primary mediastinal germ cell tumors （GCT）. Methods： A retrospective analysis was performed in the patients with pathologically confirmed GCT during 2008 - 2013. Those with the primary mediastinal GCT were enrolled and the clinical features and outcome were col- lected. Results：A total of 1 523 cases of pathologically diagnosed GCT were screened,including 163 cases of primary mediastinal GCT. 14 cases were malignant, including seminoma（ n = 6 ） , and non - seminoma（ n = 8 ）. Survival of sem- inoma was superior to that of non - seminoma（ P = 0. 015 ）. Taking account of histology, none of the surgery, chemo - or radio - therapy had prognostic value. Conclusion：Seminoma seemed to be a positive prognostic factor. The value of surgery remained elusive. Radiochemotherapy should be the main treatment mode for this disease.

关 键 词：生殖细胞瘤 纵隔肿瘤 治疗 预后 

分 类 号：R737[医药卫生—肿瘤]