p16、Ki-67在宫颈鳞状上皮病变分级诊断中的意义  

Significance of p16,Ki-67 in grading diagnosis of cervical squamous epithelial lesions

作　　者：李旭[1] 鲍健[1] 孙翠翠[1] 

机构地区：[1]锦州市中心医院病理科,辽宁锦州121000

出　　处：《现代肿瘤医学》2017年第13期2119-2121,共3页Journal of Modern Oncology

摘　　要：目的:探讨p16、Ki-67在宫颈鳞状上皮病变分级诊断中的意义。方法:收集我院2013年6月至2015年6月,阴道镜检查并宫颈活检病理127例,进行免疫组化p16、Ki-67检测,整理完整临床和病理资料作为研究对象。结果:根据127例宫颈活检HE染色及p16、Ki-67免疫组化结果修订原诊断。26例诊断为慢性宫颈炎;32例HSIL除1例考虑萎缩性改变,31例诊断HSIL;58例LSIL其中7例诊断为HSIL;11例CIN1-2中2例诊断为HSIL,9例诊断为LSIL;所有修订后HSIL,均随访1年。40例HSIL患者行Leep、宫颈锥切治疗,病理诊断除1例表现为p16、Ki-67阴性外(考虑萎缩性改变),与活检病理诊断一致。结论:联合免疫组化p16、Ki-67检测,在宫颈鳞状上皮病变分级诊断、治疗中具有重要意义,p16在肿瘤性病变中过表达更具特异性。Objective：To study the significance of p16, Ki -67 testing in grading diagnosis of cervical squamous epithelial lesions. Methods： 127 cases of cervical biopsy specimens from colposcopy were collected. The expressions of p16, Ki -67 were evaluated by immunohistochemical staining. Collate clinical and pathlogical information for subject. Results：According to HE staining and the positive expression rates, the original diagnosis were corrected in 127 cases of cervical biopsy specimens. 26 cases were diagnosed as chronic cervicitis. 7 cases were corrected as HSIL in 58 ca- ses LSIL. 2 cases were corrected as HSIL in 11 cases of CIN1 - 2.9 cases were corrected as LSIL in 11 cases of CIN1 - 2. Cases of all corrected were followed up for 1 year. 40 cases of HSIL with Leep, cervical cone cut treatment were in line with the original diagnosis, in addition to 1 case of p16, Ki - 67 negative （ consider atrophic changes）. Conclu- sion：It plays more important significance of pl6,Ki -67 testing in grading diagnosis and treatment of cervical squa- mous enithelial lesions. SPecificity of D16 is hi^her in diagnosis of cervical sauamous epithelial lesions.

关 键 词：宫颈鳞状上皮病变 P16 KI-67 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]