中国人群亚甲基四氢叶酸还原酶C677T基因位点的多态性与胃癌关系的meta分析  

Association between MTHFR C677T polymorphism and gastric cancer in Chinese population: a meta-analysis

作　　者：王建凯[1] 蔡宏懿[1] 缪国英[1] 张利娟[1] 马文[1] 胡永国[1] 冯石芳[1] 王文娟 

机构地区：[1]甘肃省人民医院放疗科,兰州730000 [2]甘肃省第三人民医院体检中心,兰州730000

出　　处：《中国普外基础与临床杂志》2017年第6期701-709,共9页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的评价中国人群亚甲基四氢叶酸还原酶(MTHFR)基因C677T位点的多态性与胃癌发生的相关性。方法计算机检索Pub Med、EMBASE、Web of Science、中国生物医学文献数据库(CBM)、中文科技期刊数据库、中国期刊数据库和万方数据库中的关于中国人群MTHFR基因C677T位点的多态性与胃癌发生关系的病例对照研究,检索时间为建库到2016年6月。采用Stata 10.0软件进行meta分析。结果共纳入13篇病例对照研究进行meta分析,其中病例组包括2 569例胃癌患者,对照组包括3 495位健康人。meta分析结果显示,对于中国人群而言,与CT基因型相比,CC基因型是保护因素[OR=0.75,95%CI为(0.67,0.85),P=0.001];与TT基因型相比,CT基因型是保护因素[OR=0.77,95%CI为(0.68,0.89),P=0.001];与TT基因型相比,CC基因型是保护因素[OR=0.56,95%CI为(0.49,0.65),P=0.02];与含T的基因型(CT+TT)相比,CC基因型是保护因素[OR=0.68,95%CI为(0.61,0.76),P=0.001];与TT基因型相比,含C的基因型(CC+CT)是保护因素[OR=0.73,95%CI为(0.60,0.89),P=0.002]。结论中国人群中MTHFR基因C677T位点的多态性与胃癌的发生相关。Objective To assess the association between MTHFR C677T polymorphism and gastric cancer in Chinese population. Methods Relevant literatures were searched from PubMed, EMBASE, Web of Science, China Biology Medicine Database, Chinese Science and Technology Academic Journal, Chinese Journal Full-Text Database, and Wanfang database, the period ranged from their inception to June 2016, and then meta analysis was performed by Stata 10.0 software. Results A meta-analysis of 13 case-control studies enrolled was performed, including 2 569 gastric cancer patients and 3 495 controls. Results of meta-analysis showed that, in Chinese population, CC was a protective factor for gastric cancer comparing with CT （ OR=0.75, 95% CI is （0.67, 0.85）, P=0.001 ）, CT was a protective factor for gastric cancer comparing with TT （ OR=0.77, 95% CI is （0.68, 0.89）, P=0.001 ）, CC was a protective factor for gastric cancer comparing with TT （OR=0.56, 95% CI is （0.49, 0.65）, P=0.02）, CC was a protective factor for gastric cancer comparing with CT＋TT / OR=0.68, 95% CI is （0.61, 0.76）, P=0.001 ）, CC＋CT was a protective factor for gastric cancer comparing with TT / OR=0.73, 95% CI is （0.60, 0.89）, P=0.002） . Conclusion There is association between MTHFR C677T polyrnorphism and gastric cancer in Chinese population.

关 键 词：胃癌 亚甲基四氢叶酸还原酶 基因多态性 META分析 

分 类 号：R735.2[医药卫生—肿瘤]