帕罗西汀对抑郁症及其IL-1、IL-6、hs-CRP水平的影响  

Correlation of IL-1、IL-6、hs-CRP for Paroxetine Treatment New Depression Patients

作　　者：何晓燕[1] 连俊红[1] 

机构地区：[1]洛阳市精神卫生中心,河南洛阳471013

出　　处：《河南科技大学学报（医学版）》2017年第2期137-139,共3页Journal of Henan University of Science & Technology:Medical Science

摘　　要：目的探讨帕罗西汀治疗首发抑郁症及其对白细胞介素-1(IL-1)、白细胞介素-6(IL-6)、高敏C反应蛋白(hs-CRP)水平的影响。方法选择50例我院住院治疗的新发抑郁症患者为观察组,分别在治疗前、治疗后1周、4周、6周后抽血检测IL-1、IL-6和hs-CRP,并进行汉密尔顿抑郁分级量表(HAMD)评分。选择50例同期健康体检职工的血清作为对照组测定IL-1、IL-6和hs-CRP。结果观察组IL-1、IL-6和hs-CRP均高于对照组(均P<0.05);观察组的IL-1、IL-6和hs-CRP在帕罗西汀治疗1、4、6周后均明显降低,HAMD评分也降低(均P<0.05)。结论帕罗西汀治疗首发抑郁症的疗效可能与IL-1、IL-6和hs-CRP变化有关。Objective To explore paroxetine treatment the first-episode depression and its effect of serum IL-1, IL-6 and c-reactive protein （hs-CRP） levels. Methods 50 cases of first-episode depression patients were selected in our hospital as observation group. The IL-1 ,IL-6 and hs-CRP were detected before and after paroxetine treatment 1 week, 4 weeks, 6 Weeks, and the Hamilton depression rating scale （HAMD） scores also was assessment. At the corresponding time period, the IL-1, IL-6 and hs-CRP of 50 cases of health examination were detected as the control group. Results The IL-I,IL-6 and hs-CRP in observation group were higher than that of control group （ all P 〈 0.05）. After paroxetine treatment the IL-1 ,IL-6 and hs-CRP were significantly decreased in observation group （ all P 〈 0.05） , and HAMD scores also was obviously decreased （P 〈0. 05）. Conclusion The efficacy of paroxetine in the treatment of first-episode depression might be associated with change of IL-1, IL-6 and hs-CRP.

关 键 词：抑郁症 帕罗西汀 细胞因子 

分 类 号：R749.05[医药卫生—神经病学与精神病学]