血清胃蛋白酶原和IL-23用于胃癌早期诊断的价值  

Value of serum pepsinogen and IL-23 in early diagnosis of gastric cancer

作　　者：贾萌萌[1] 周英发[1] 赵治国[1] 刘超[1] 郑紫恒 黄艳玲[2] 温静[2] 任景丽[3] 

机构地区：[1]郑州大学第二附属医院消化内科,郑州450014 [2]郑州大学第二附属医院消化内镜室,郑州450014 [3]郑州大学第二附属医院病理科,郑州450014

出　　处：《郑州大学学报（医学版）》2017年第3期366-370,共5页Journal of Zhengzhou University(Medical Sciences)

摘　　要：目的:探讨血清胃蛋白酶原(PG)和IL-23用于胃癌早期诊断的价值。方法:收集40例慢性非萎缩性胃炎、38例单纯慢性萎缩性胃炎、33例慢性萎缩性胃炎伴肠上皮化生、30例异型增生及36例胃癌患者的空腹外周血,采用乳胶增强免疫比浊法测定血清PG亚群PGⅠ、PGⅡ的水平,采用ELISA法测定血清IL-23的水平。分析患者血清PGⅠ和IL-23的相关性。采用ROC分析血清PGⅠ、PGⅠ/PGⅡ(PGR)及IL-23对胃癌早期诊断的价值。结果:人胃黏膜癌变过程中血清PGⅠ、PGR下降,IL-23升高。血清PGⅠ与IL-23水平在慢性萎缩性胃炎伴肠上皮化生和胃癌组呈负相关(r=-0.87、-0.73,P<0.001)。ROC结果显示血清PGR、PGⅠ、IL-23诊断胃癌的AUC值依次为0.99、0.94、0.86。结论:血清PGⅠ、PGR、IL-23可用于胃癌及胃癌癌前病变的大规模筛查。Aim： To investigate the value of serum pepsinogen and IL-23 in the early diagnosis of gastric cancer.Methods： The peripheral blood samples of patients suffering from chronic non-atrophic gastritis（ n = 40）,chronic atrophic gastritis without intestinal metaplasia（ IM）（ n = 38）,chronic atrophic gastritis with IM（ n = 33）,gastric epithelial dysplasia（ n = 30） and gastric cancer（ n = 36）. Latex-enhanced immunoturbidimetry method was used to quantitatively determine the serum pepsinogen subgroups（ PGⅠ,PGⅡ）. ELISA was used for determining the level of IL-23. Correlation between PGⅠand IL-23 in serum of the patients was analyzed. The value of serum PGⅠ,PGR（ PGⅠ/PGⅡ） and IL-23 in early diagnosis of gastric cancer was assessed by the receiver operating characteristic curve（ ROC）. Results： The serum PGⅠand PGR decreased,IL-23 increased in the process of gastric mucosal carcinogenesis. The serum PGⅠand IL-23 were negatively correlated in patients with chronic atrophic gastritis with IM and patients with gastric cancer（ r =-0. 87,-0. 73,P 〈 0. 001）.ROC results showed that the AUC values of PGR,PGⅠ and IL-23 in the diagnosis of gastric cancer were 0. 99,0. 94 and0. 86. Conclusion： Serum PGⅠ,PGR,and IL-23 may be used for the screening of the patients with gastric cancer and precancerous lesions.

关 键 词：胃蛋白酶原 IL-23 幽门螺杆菌 胃癌 

分 类 号：R735.2[医药卫生—肿瘤]