胃息肉临床病理特征与幽门螺杆菌感染状态的关系  

Relationship between gastric polyps and Helicobacter pylori infection

作　　者：蒋宇亮 李伟聪[3] 赵子夜 李白容[2] 张静[2] 宁守斌[2] 

机构地区：[1]河北北方学院,河北省张家口市075061 [2]解放军空军总医院消化科,北京市100142 [3]北京市航天中心医院老年二科,北京市100040 [4]解放军第二七三医院外一科,新疆维吾尔自治区库尔勒市841007

出　　处：《世界华人消化杂志》2017年第15期1400-1404,共5页World Chinese Journal of Digestology

摘　　要：目的探讨胃息肉临床病理特征与幽门螺杆菌(Helicobacter pylori,H.pylori)感染状态的关系.方法纳入2013-01/2016-12解放军空军总医院消化内镜中心胃镜检查39572例次,共检出胃息肉2445例次(检出率为6.18%).比较不同病理性质胃息肉的分布规律,年龄差异使用t检验,年龄分组、性别、H.pylori感染状态、是否多发、生长位置的差别用χ~2检验.结果在39572例次胃镜检查中有2445例次检出胃息肉,按照纳入标准筛选后共有1339例次胃镜检查结果纳入研究.共发现增生性息肉、胃底腺息肉、腺瘤性息肉分别为771例、559例、9例,其中991例为多发性息肉.针对增生性息肉和胃底腺息肉的因子分析发现,胃底腺息肉具有更高的女性构成比、更低的H.pylori阳性率、倾向于多发、好发于胃底及胃体等特点(P<0.05).两者在年龄分布上无显著差别.多发性息肉的H.pylori阳性率显著低于单发性息肉(P<0.05).结论胃底腺息肉在胃息肉构成比中有增高的趋势.胃底腺息肉具有倾向于多发、H.pylori阳性率低、好发于胃底及胃体部等特点,其检出率和在胃息肉中构成比的提高可能是导致临床检出的多发性息肉较之单发息肉具有更低的H.pylori感染率的重要原因.因此在临床治疗多发性胃息肉时应考虑到上述事实并予以特殊关注.AIM To explore the relationship between the clinicopathological features of gastric polyps and the infection status of Helicobacter pylori （hi. pylori）. METHODS Data for gastric polyps detected by gastroscopy at the Endoscopy Center of Air Force General Hospital from January 2013 to December 2016 were collected, and their clinical and pathological features were analyzed. The difference in age was analyzed by t test. The distributions of age, sex, H. pylori infection status, number of polyps, and location were analyzed by ;2 test. RESULTS In 39572 cases of endoscopic examinations, 2445 cases of gastric polyps were detected. After excluding some cases according to the inclusion criteria, a total of 1339 cases of gastric polyps were included in this study. There were 771, 559 and 9 cases of hyperplastic, fundic gland and adenomatous polyps, respectively. Multiple polyps were detected in 991 cases. Fundic gland polyps tended to affect females and have a lower positive rate of H. pylori and more multiple lesions, and involve the fundusand body of the stomach （P 〈 0.05）. There was no significant difference in age distribution between the two groups. The positive rate of H. pylori for multiple lesions was lower than that for single lesion （P 〈 0.05）. CONCLUSION Fundic gland polyps have a low H. pylori positive rate and tend to be multiple and occur in the fundus and the body of the stomach. The detection rate of fundic gland polyps increases, which may lead to a lower H. pylori positive rate in multiple polyps than in single polyp.

关 键 词：胃息肉 幽门螺杆菌 质子泵抑制剂 胃镜检查 

分 类 号：R573[医药卫生—消化系统]