山东省女性HPV6/11和HPV16/18感染情况分析  

Prevalence of human papillomavirus 6/11 and 16/18 among women in Shandong Province

作　　者：田欣欣 姜玲波 王睿 彭德志 卜范峰 李雅文 张丽冉 王新国 谢风祥 祁德波 

机构地区：[1]济南金域医学检验中心基因室,济南250101 [2]济南金域医学检验中心病理室,济南250101

出　　处：《中国性科学》2017年第6期76-80,共5页Chinese Journal of Human Sexuality

摘　　要：目的:对山东省女性人乳头状瘤病毒(human papillomavirus,HPV)6/11和HPV16/18感染的检测结果进行回顾分析,以了解山东省各年龄段、各地区女性HPV的感染状况。方法:采用实时荧光定量PCR技术,对2012年1月至2016年6月间济南金域医学检验中心收集的3995例和7508例样本,分别进行HPV6/11或HPV16/18检测,并对检测结果进行回顾分析。结果:HPV6/11检测的阳性率为27.2%(1085/3995),明显高于HPV16/18检测的5.1%(384/7508)。两种HPV检测的阳性率呈现不对称双峰分布,均以<20岁组阳性率最高,分别为35.5%和21.7%。随后HPV6/11和HPV16/18的阳性率随年龄增长而逐渐下降,后HPV6/11的阳性率又逐渐升高至51~60岁组的34.3%和>60岁组的43.8%;HPV16/18检测的阳性率在>60岁组也略有上升,为3.4%。各地区中鲁中(31.6%)和鲁西(30.6%)HPV6/11的阳性率要高于鲁东(22.1%)和鲁北(21.7%);HPV16/18的检出率以鲁中(16.3%)最高,而鲁东最低(4.1%)。结论:本研究结果反映了山东省女性HPV6/11、HPV16/18感染的最新分布状况,对掌握山东省女性HPV感染的流行病学特征,为子宫颈癌筛查和HPV疫苗的接种提供科学依据。Objectives： To investigate the prevalence of human papillomavirus（HPV） 6/11 and 16/18 among women at different ages and in different regions in Shandong Province. Methods： The 3,995 and 7,508 samples collected were by Jinan King Med Diagnostics Center from January 2012 to June 2016 were tested for HPV 6/11 and 16/18 with real-time fluorescence quantitative PCR technology respectively. The overall prevalence,age-specific prevalence and region-specific prevalence were documented and analyzed. Results： The prevalence of HPV 6/11（1085 cases,27. 2%） was much higher than that of HPV 16/18（384 cases,5. 1%）. Age-specific prevalence showed an asymmetrical ‘two-peak＇pattern for both HPV 6/11 testing and 16/18 testing,with 20 years old group（35. 5% for HPV 6/11 and 21. 7% for HPV 16/18） presenting the highest HPV-positive rates.The prevalence of both HPV testing gradually declined with age,followed by a second peak in 51 ~ 60 years old group（34. 3%） and 60 years old group（43. 8%） for HPV 6/11 testing,and in 60 years old group（3. 4%）for 16/18 testing,respectively. The positive rates of HPV 6/11 in central area（31. 6%） and west area（30. 6%）were much higher than those in other areas,while the positive rates of HPV 16/18 were highest in central area（16. 3%） and lowest in east area（4. 1%）. Conclusion： The present study demonstrates that the prevalence of HPV 6/11 and 16/18 vary significantly among different ages and regions in Shandong Province,which represents the most current survey of the prevalence of HPV 6/11 and 16/18,and can serve as valuable reference to guide cervical cancer screening and HPV vaccination programs.

关 键 词：人乳头瘤病毒 子宫颈癌筛查 HPV疫苗 山东 

分 类 号：R737.33[医药卫生—肿瘤]