胃肠安方加减联合化疗治疗Ⅳ期老年结直肠癌临床研究  

Clinical research of Modified Weichang'an Decoction combined with chemotherapy in treating elderly patients with stage Ⅳ colorectal cancer

作　　者：朱莹杰[1] 孟丹[1] 王浩[2] 徐一[1] 郑坚[1] 陶丽[1] 顾缨[1] 

机构地区：[1]上海中医药大学附属龙华医院肿瘤科,上海200032 [2]河北省中医院肿瘤一科,河北石家庄050011

出　　处：《上海中医药杂志》2017年第6期46-48,55,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：第五批全国老中医药专家学术经验继承工作项目(LH30.004);上海市卫计委青年科研项目(20134y141)

摘　　要：目的观察胃肠安方加减联合以5-氟尿嘧啶为基础的化疗方案治疗Ⅳ期老年结直肠癌的临床疗效。方法将133例Ⅳ期老年结直肠癌患者分为治疗组(68例)和对照组(65例),两组患者均以5-氟尿嘧啶为基础方案化疗3个疗程,治疗组同时采用胃肠安方加减口服。比较两组近期疗效、毒副反应、生活质量及总生存期情况。结果 (1)近期疗效中,两组总有效率和疾病控制率无统计学差异(P>0.05);(2)治疗组患者生活质量优于对照组(P<0.01);(3)治疗组中位PFS和中位OS均比对照组显著延长(P<0.05);(4)治疗组白细胞减少和末梢神经毒性等毒副反应均低于对照组(P<0.05,P<0.01)。结论胃肠安方加减联合以5-氟尿嘧啶为基础的化疗方案治疗Ⅳ期老年结直肠癌,可提高患者近期疗效,减少毒副反应,改善生活质量,延长生存期。Objective To observe the clinical efficacy of Modified Weichang＇ an Decoction combined with 5-fluorouracil based chemotherapy in treating elderly patients with stage IV colorectal cancer. Methods 133 elderly patients with stage 1V colorectal cancer were divided into the treatment group （68 cases） and control group （65 cases）. All patients were treated with 5-fluorouracil based chemotherapy for 3 courses. In addition,the treatment group was orally treated with Modified Weichang＇ an Decoction. The short-term efficacy, toxic and adverse reactions, quality of life and overall survival in the two groups were compared. Results （~）In short-term efficacy, there were no statistically significant differences on the total effective rate and disease control rate between the two groups （ P 〉 0.05 ）. （~）The life quality of patients in the treatment group was better than that in the control group （P 〈 0.01 ）. （~）The median PFS and median OS in the treatment group were significantly longer than those in the control group （P 〈 O. 05 ）. （~The toxic and adverse reactions such as leukocyte reduction and peripheral neurotoxicity in the treatment group were less than those in the control group （ P 〈 0.05, P 〈 0.01 ）. Conclusion Modified Weichang＇ an Decoction combined with 5-fluorouracil based chemotherapy can enhance the short-term efficacy, reduce the toxic and adverse reactions,improve the life quality and prolong the survival in treating elderly patients with stage 1V colorectal cancer.

关 键 词：结直肠癌 胃肠安方 生活质量 生存期 老年 

分 类 号：R735.34[医药卫生—肿瘤]