lncRNA AC007009.1在非小细胞肺癌组织中的表达及其临床意义  

Expression of lncRNA AC007009.1 in tissues of non-small cell lung cancer and its clinical significance

作　　者：程序[1] 余玲[1] 唐波[2] 王勇[1] 

机构地区：[1]四川省自贡市第四人民医院病理科,四川自贡643000 [2]四川省自贡市第四人民医院胸外科,四川自贡643000

出　　处：《中国肿瘤生物治疗杂志》2017年第6期645-649,共5页Chinese Journal of Cancer Biotherapy

基　　金：国家自然科学基金项目(No.81301910)~~

摘　　要：目的:探讨lncRNA AC007009.1在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达及其临床意义。方法:收集2011年6月至2016年6月四川省自贡市第四人民医院105例NSCLC患者;通过实时荧光定量PCR法检测lncRNA AC007009.1在105例NSCLC组织、72例癌旁组织及33正常肺组织中的表达水平,分析lncRNA AC007009.1的表达与患者部分临床病理学特征之间的关系,了解lncRNA AC007009.1的表达与患者OS和PFS关系及对患者预后的影响。结果:LncRNA AC007009.1在105例NSCLC癌组织中的表达水平明显高于癌旁组织及正常肺组织(5.30±1.96 vs 1.01±0.33、0.99±0.29,均P<0.01),LncRNA AC007009.1的表达水平与患者癌症分期、远处转移、病理类型及生存状态明显有关(P<0.05)。高表达lncRNA AC007009.1患者的OS及PFS较低表达患者明显缩短(P<0.01),Cox多因素回归模型分析显示,lncRNA AC007009.1的表达水平、淋巴远处转移及临床分期是NSCLC独立的预后影响因素(P<0.05)。结论:lncRNA AC007009.1参与调节NSCLC的发生发展,可作为潜在的NSCLC诊断和预后评估的分子标志物。Objective：To investigate the expression and clinical significance of lncRNA AC007009.1 in tissue samples of non small cell lung cancer （NSCLC）. Methods： The expression of lncRNA AC007009.1 in 105 NSCLC tissue samples, 72 adjacent normal tissue samples and 33 normal tissue samples was detected by qRT PCR method; and the relationship between lncRNA AC007009.1 expression and clinical pathological characteristics of NSCLC was analyzed; in addition, the correlation between lncRNAAC007009.1 expression and the OS and PFS of NSCLC patients was also analyzed. Results： Expression of lncRNAAC007009.1 was significantly increased in tumor tissues than that in noncancerous tissues （5.30±1.96 vs 1.01±0.33, 0.99±0.29,P〈0.01）. AC007009.1 expression was positively correlated with disease stage,distant metastasis,pathological type and survival status （P〈0.05）; Moreover, the OS and PFS of patients with high lncRNAAC007009.1 expression were significantly shorter than the patients with low expression （P〈0.01）. Cox multivariate analysis also indicated that lncRNAAC007009.1 expression, disease stage, distant metastasis were the independent prognostic markers for NSCLC （all P〈0.05）. Conclusion： LncRNA AC007009.1 is involved in the development of NSCLC, and can be used as a molecular marker for the diagnosis and prognosis of non small cell lung cancer.

关 键 词：IncRNA AC007009.1 非小细胞肺癌 癌旁组织 表达水平 

分 类 号：R734.2[医药卫生—肿瘤] R730.2[医药卫生—临床医学]