CD151及MMP-7在肺腺癌组织中的表达及其临床意义  

The expressions of CD151 and MMP-7 in lung adenocarcinoma tissues and their clinical significance

作　　者：杨杰[1] 袁晓晗[1] 李凯[1] 

机构地区：[1]天津医科大学肿瘤医院肺部肿瘤科国家临床医学研究中心天津市肿瘤防治重点实验室天津市肺癌诊治中心天津市恶性肿瘤临床医学研究中心,天津300060

出　　处：《肿瘤》2017年第6期624-632,共9页Tumor

摘　　要：目的:探讨CD151及基质金属蛋白酶7(matrix metalloproteinase-7,MMP-7)在肺腺癌组织中的表达及其临床意义。方法:应用免疫组织化学法检测149例肺腺癌组织及40例癌旁组织中CD151及MMP-7蛋白的表达情况,并进一步分析CD151与MMP-7蛋白表达间的相关性及其与患者临床病理特征间的关系,分析影响患者无病生存期的因素。结果:肺腺癌组织中CD151和MMP-7的阳性表达率均高于癌旁组织(P值均<0.05)。CD151蛋白表达与患者吸烟、淋巴结转移及TNM分期有关(P值均<0.05),MMP-7蛋白表达与患者淋巴结转移及TNM分期有关(P值均<0.05)。肺腺癌组织中,CD151与MMP-7的表达呈正相关(r=0.322,P<0.05)。CD151阳性表达者的无病生存期短于阴性表达者(P=0.005),CD151与MMP-7均呈阳性表者的无病生存期明显短于二者均呈阴性表达者(P=0.004)。CD151是影响肺腺癌患者无病生存的独立因素(P<0.05)。结论:肺腺癌组织中CD151和MMP-7的阳性表达率较高,CD151蛋白阳性表达的肺腺癌患者无病生存期较短。Objective： To observe the expressions of CD151 and matrix metalloproteinase-7 （MMP-7） in lung adenocarcinoma tissues and their clinical significance.Methods： The expressions of CD151 and MMP-7 in 149 lung adenocarcinoma tissue samples and 40 adjacent normal tissue samples were detected by immunohistochemistry. The relationship between the expressions of CD151 and MMP-7 and their correlation with the clinicopathological data were analyzed. The disease-free survival （DFS）-related factors were examined.Results： The positive expression rates of CD151 and MMP-7 in lung adenocarcinoma tissues were higher than those in adjacent normal tissues （both P 〈 0.05）. The CD151 expression was associated with smoking, lymph node metastases and TNM stage （all P 〈 0.05）. The MMP-7 expression was associated with lymph node metastases and TNM stage （both P 〈 0.05）. There was a positive correlation between CD151 and MMP-7 expressions in lung adenocarcinoma tissues （r = 0.322, P 〈 0.05）. The DFS of patients with positive expression of CD151 was shorter than that of the patients with negative expression of CD151 （P= 0.005）. The DFS of patients with coexpression of CD151 and MMP-7 was shorter than that of the patients with negative expressions of CD151 and MMP-7 （P= 0.004）. CD151 was an independent DFS-related factor in patients with lung adenocarcinoma （P 〈 0.05）.Conclusion： The positive expression rates of CD151 and MMP-7 are high in lung adenocarcinoma tissues. The DFS of patients with positive expression of CD151 is relatively short.

关 键 词：肺肿瘤 基质金属蛋白酶7 抗原 CD151 预后 

分 类 号：R734.2[医药卫生—肿瘤]