抗VEGF在新生血管性青光眼治疗中的早期临床观察  

Effects of anti-VEGF and cyclophotocoagulation on the treatment of neovascular glaucoma

作　　者：张磊[1] 刘大川[1] 边俊杰[1] 吴航[1] 

机构地区：[1]首都医科大学宣武医院眼科,北京100053

出　　处：《临床眼科杂志》2017年第3期253-255,共3页Journal of Clinical Ophthalmology

摘　　要：目的观察抗VEGF药物联合睫状体光凝治疗新生血管性青光眼的早期疗效。方法将11例新生血管性青光眼患者随机分为抗VEGF联合睫状体光凝治疗组和单纯睫状体光凝治疗组,所有患者在治疗前行起始眼压监测,在抗VEGF治疗和睫状体光凝治疗后第1、3、5、7、14天进行眼压监测,观察两组的眼压变化情况。结果联合治疗组抗VEGF治疗后,眼压由(58.50±10.32)mm Hg降低到(44.00±5.48)mm Hg(P=0.021)。睫状体光凝治疗后1天,联合治疗组眼压(26.21±4.13)mm Hg,较单纯睫状体光凝治疗组眼压(32.20±3.99)mm Hg低(t=1.381,P=0.041)。睫状体光凝治疗后第3、5、7、14天联合治疗组眼压分别为(27.45±8.35)、(24.75±5.15)、(18.15±2.41)、(17.91±2.31)mm Hg,单纯治疗组为(28.20±3.58)、(23.59±4.14)、(19.71±1.42)、(18.10±2.06)mm Hg,组间比较无统计学差异。结论抗VEGF能够在早期有效的控制眼压,可以作为新生血管性青光眼的早期治疗手段,但联合治疗会有更好的疗效。Objective To study the effects of anti-VEGF drugs combined with cyclophotocoagulation in the treatment of neovascular glaucoma. Methods 11 cases of neovascular glaucoma received anti-VEGF combined with cyclophotocoagulation or cyclophotocoagulation alone. IOP were measured before and up to 2 weeks after treatment. Results IOP decreased from 58. 50 ± 10. 32 to 44 ± 5. 48（ P = 0. 021） after anti-VEGF treatment. One day after combined treatment,IOP in patients treated with anti-VEGF was lower（ 26. 21 ± 4. 13 mm Hg） than IOP in patients treated with cyclophotocoagulation alone（ 32. 20 ± 3. 99 mm Hg; t = 1. 381 and P = 0. 041）. However,there was no difference in IOP between the two groups after day 1. Conclusions Anti-VEGF treatment provides an additional reduce in IOP in short term.

关 键 词：新生血管性青光眼 抗VEGF 睫状体光凝 

分 类 号：R775[医药卫生—眼科]