生育酚的合成及工艺优化  

Synthesis and Optimization of Alpha Tocopherol

作　　者：许鑫[1] 宋亚[1] 周崴海 郝秀斌[1] 倪海华[1] 阴启明[1] 

机构地区：[1]扬子江药业集团有限公司,江苏泰州225321

出　　处：《广东化工》2017年第12期95-95,63,共2页Guangdong Chemical Industry

基　　金：[基金项目]多烯磷脂酰胆碱及冻干制剂

摘　　要：文章介绍了α-生育酚的合成工艺,通过TMHQ与异植物醇反应,以81%~87%的收率高效便捷的合成了生育酚。产物生育酚通过核磁共振谱(1H NMR)及高分辨质谱(GC-MS)进行了结构表征。本合成路线条件温和,操作简便,收率较高,产品质量稳定,适合工业化生产。The paper introduces the synthesis process of Alpha Tocopherol. Alpha Tocopherol has been conveniently synthesized in 81%-87 % yields through the reaction between TMHQ and Isophytol. All compounds were confirmed by I H NMR and HRMS spectroscopic analysis. This synthetic method was in mild condition, simple operation, high yield, product quality is stable, suitable for industrial production.

关 键 词：生育酚 抗氧化剂 合成 

分 类 号：TQ[化学工程]