Albumin nanoreactor-templated synthesis of Gd_2O_3/CuS hybrid nanodots for cancer theranostics  

Gd_2O_3/CuS复合白蛋白纳米粒的合成及其在肿瘤诊疗一体化中的应用（英文）

作　　者：温茹 吕小燕 杨涛 李誉 唐永安 柏欣 柯亨特 沈钧康 陈华兵 

机构地区：[1]Department of Radiology,Second Affiliated Hospital of Soochow University [2]Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases,and College of Pharmaceutical Sciences,Soochow University [3]National Engineering Research Center for Nanomedicine,and College of Life Science and Technology,Huazhong University of Science and Technology

出　　处：《Science China Materials》2017年第6期554-562,共9页中国科学（材料科学（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (31422021, 51473109, and 81501585);National Basic Research Program of China (2014CB931900);Natural Science Foundation of Jiangsu Province of China (BK20150348);Natural Science Foundation of the Jiangsu Higher Education Institutions of China (15KJB310019);China Postdoctoral Science Foundation (2015M570475 and 2016T90496);Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD);Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-PsychoDiseases, Open Fund of CAS Key Laboratory of Nano-Bio Interface (16NBI02);Jiangsu Undergraduates Innovation and Entrepreneurship Program (20150285075Y)

摘　　要：It remains a great challenge to explore the facile way to fabricate multi-component nanoparticles in theranostic nanomedicine. Herein, an albumin nanoreactor templated synthesis of theranostic Gd203/CuS hybrid nanodots （NDs） has been developed for multimodal imaging guided photothermal tumor ablation. Gd2O3/CuS NDs are found to possess particle size of 4.4 ± 1.1nm, enhanced longitudinal relaxivity, effective photothermal conversion of 45.5%, as well as remarkable near-infrared fluorescence （NIRF） from Cy7.5-conjugated on albumin corona. The Gd203/CuS NDs further exhibited good photostability, en- hanced cellular uptake, and preferable tumor accumulation. Thus, the Gd203/CuS NDs generate remarkable NIRF imag- ing and Tl-weighted magnetic resonance （MR） imaging, and simultaneously result in effective photothermal tumor ab- lation upon irradiation. The albumin nanoreactor provides a facile and general strategy to synthesize multifunctional nanoparticles for cancer theranostics.本文采用白蛋白纳米反应器合成了Gd_2O_3/CuS双组分复合纳米粒,并将其成功应用于肿瘤的诊断与治疗.研究发现复合纳米粒中Gd/Cu比例可有效调控其纵向弛豫系数,其磁共振造影性能数倍于Gd-DTPA.同时,可通过化学偶联在蛋白表面修饰近红外荧光探针Cy7.5,得到Cy7.5-Gd_2O_3/CuS纳米粒,实现近红外荧光成像与磁共振成像的多模态成像.该复合纳米粒具有良好的光稳定性、较高的光热转换系数、较强的细胞摄取和肿瘤靶向效应,实现了精确的肿瘤光热消融治疗.该方法提供了一种快速、简便、通用的多组分纳米粒构建平台,为肿瘤诊疗一体化纳米材料的发展提供了新的契机.

关 键 词：albumin nanoreactor NANODOT THERANOSTICS pho tothermal therapy magnetic resonance imaging 

分 类 号：R730[医药卫生—肿瘤] TB383.1[医药卫生—临床医学]