鲁西南地区中孕期产前筛查中位数的建立与应用效果评估  

Establishment and the application of median serum markers for second trimester screening in Southwest of Shandong Province

作　　者：江利青[1] 董海新[1] 颜金艳[1] 金呈强[1] 刘海峰[1] 谷文静[1] 张秀[1] 靳雪梅[1] 

机构地区：[1]济宁医学院附属医院检验科,山东济宁272029

出　　处：《中国优生与遗传杂志》2017年第6期69-70,27,共3页Chinese Journal of Birth Health & Heredity

基　　金：济宁医学院附属医院"苗圃"科研项目;项目编号:MP-2015-025

摘　　要：目的研究建立与本实验室检测人群、检测指标性能相匹配的中位数,及本地中位数建立前后对筛查效能的影响。方法对本院2011年1月至2012年12月进行孕中期血清学筛查的数据利用软件对月度中位数的倍数(Mo M)进行总体回归分析及校正,使得Mo M中值校正到1.0水平,并应用至2012年12月后的进行筛查的人群,评估可能怀唐氏综合征胎儿的风险值。对比校正本地中位数前后筛查阳性率的变化。结果建立本地中位数前后唐氏筛查阳性率分别为2.3%、5.8%,差异有统计学意义(P<0.05)。结论建立本地化中位数及对筛查系统进行数据监测与分析,有助于提高筛查效能。Objective： To establish and analyze the efficiency of the median serum markers for second trimester screening in southwest of Shandong province. Methods： The data of serological screening in the second trimester of our hospital from January 2011 to December 2012 were retrospectively collected. Multiples of the Median （MOM） were analyzed and corrected to 1.0. Then the MoM were used for second trimester screening since December 2012, and the risk of pregnant women with Down＇ s syndrome was evaluated. Comparison had been done before and after the establishment of MoM. Results： The positive rate of pregnant women with Down＇ s syndrome was 2.3% and 5.8% respectively before and after the establishment of MoM, with statistically difference （P〈0.05） . Conclusion： It is useful toestablish and apply the laboratory-specific median during the prenatal screening and diagnosis.

关 键 词：产前筛查 唐氏综合征 孕中期 中位数 

分 类 号：R714.5[医药卫生—妇产科学]