LncRNA BANCR在肿瘤中的研究进展  

Long non-coding RNA BANCR in the tumor progress

作　　者：刘诗聪[1] 王世慧[1] 李佩玲[1] 

机构地区：[1]哈尔滨医科大学附属第二医院,黑龙江哈尔滨150086

出　　处：《中国优生与遗传杂志》2017年第6期123-125,134,共4页Chinese Journal of Birth Health & Heredity

摘　　要：长链非编码RNA(Long non-coding RNA)是一组长度大于200nt、无特异完整的开放阅读框、无蛋白编码功能的RNA,在总nc RNA中占有相当大的比例。其中BRAF-活化的非编码RNA(BRAF-acticited long non-coding RNA BANCR)作为在恶性黑素细胞瘤中新发现的lnc RNA,被认为是人类最重要的原癌基因之一,但有研究表明BANCR在某些肿瘤中可以作为抑癌因子抑制肿瘤的发生发展。本研究对BANCR参与肿瘤的发生发展进行了探讨,并对BANCR在不同肿瘤中的作用机制进行综述,为肿瘤的早期诊断和治疗提出新的展望。Long chain noncoding RNAs （Long noncoding RNAs） is a group RNA that greater than 200 nt, and has no specific complete open reading frame, no function of protein-coding RNA, occupies a considerable proportion in the total ncRNA. The mutated BRAF - acticited long non - coding RNA （BANCR） which recently was found in malignant melanin cell tumor is considered to be one of the most important human proto-oncogene, but studies have shown that BANCR in some tumors can be used as a tumor suppressor factors inhibiting tumor development.This study probes into BANCR to participate in the development of tumors, and the mechanis in different tumors to generalize, putting forward new insight for the early diagnosis and treatment of tumors.

关 键 词：BANCR 长链非编码RNA 肿瘤 

分 类 号：R73-3[医药卫生—肿瘤]