阻断Hedgehog信号通路治疗肿瘤的研究进展  

Research advance of blocking Hedgehog signaling pathway in the treatment of tumors

作　　者：朱凌霄[1] 刘陶文[2] 

机构地区：[1]桂林医学院研究生学院,广西桂林541004 [2]广西壮族自治区南溪山医院,广西桂林541002

出　　处：《华夏医学》2017年第2期156-160,共5页Acta Medicinae Sinica

基　　金：广西医疗卫生适宜技术研究与开发资助项目(S201507)

摘　　要：Hedgehog信号通路是调控胚胎发育、维持干细胞及组织动态平衡的关键,属于高度保守的传导系统。近十几年来,研究发现Hh信号通路异常激活与肿瘤发生的关系密切,针对此通路为靶点治疗某些恶性肿瘤取得明显疗效,有关研究成果为肿瘤的治疗提供了新思路。Hedgehog（ Hh） signaling pathway is the key to regulating embryonic development,maintaining the dynamic balance of stem cell and tissue,and it belongs to highly conserved conduction system. In recent decades,it has been found that abnormal activation of Hh signaling pathway is closely related to tumorigenesis. It has been found that blocking Hh signaling pathway has a significant effect on the treatment of these malignancies. So,the research results will provide a new idea for the treatment of tumor.

关 键 词：HEDGEHOG信号通路 肿瘤 靶向治疗 

分 类 号：R730.231[医药卫生—肿瘤]