促肾上腺皮质素释放激素结合蛋白用于肝癌患者的诊断价值  

Diagnostic value of corticotropin-releasing hormone binding protein in hepatocellular carcinoma

作　　者：黄宇博[1] 蒋振华[1] 马曼茹 吕勋[3] 李修岭[1] 

机构地区：[1]郑州大学人民医院消化内科,450000 [2]新乡医学院,河南新乡453000 [3]郑州人民医院消化内科,450000

出　　处：《中国实用医刊》2017年第11期13-15,共3页Chinese Journal of Practical Medicine

基　　金：河南省医学科技攻关计划重点项目（201402027）

摘　　要：目的 探讨促肾上腺皮质素释放激素结合蛋白（CRHBP）用于和乙型肝炎病毒感染相关的原发性肝癌患者临床诊断的意义和价值.方法 收集2015年8月至2016年2月至郑州大学人民医院就诊者114例作为研究对象,分为乙型肝炎病毒感染相关的原发性肝癌组（n=46）,乙肝肝硬化组（n=36）和健康对照组（n=32）.应用酶联免疫吸附剂测定法（ELISA）测定各组血清样本中CRHBP和甲胎蛋白（AFP）的表达水平.结果 CRHBP在肝细胞癌组患者血浆中的表达量高于肝硬化及健康对照组,差异有统计学意义（P〈0.05）.AFP、CRHBP诊断肝癌的敏感度分别为51.4%、80.4%,特异度分别为96.7%、72.1%;采用AFP、CRHBP平行试验的联合检测方法,肝癌患者的敏感度和特异度分别达到93.5%和69.1%.结论 CRHBP具有作为肝癌诊断的血清学指标的潜能.通过与AFP的联合检测,可以明显提高肝癌患者的检出率.Objective To investigate the value of corticotropin-releasing hormone binding protein（CRHBP） in diagnosing the hepatitis B virus infection related primary hepatocellular carcinoma（HCC）.Methods A total of 114 patients from August 2015 to February 2016 in Zhengzhou university people＇s hospital were sellected and regarded as the research objects.They were divided into three groups, the HBV infection related HCC group（n=46）, the HBV infection related liver cirrhosis group（n=36） and the control group（n=32）.The serum levels of CRHBP and AFP were measured by ELISA.Results The serum CRHBP levels in the patients with HCC were higher than those in the patients with liver cirrhosis and the control group, there were significant differences（P〈0.05）.The sensitivity of AFP and CRHBP in diagnosing HCC was 51.4% and 80.4%, while the specificity were 96.7% and 72.1%.The sensitivity and specificity by parallelly combined detection of AFP and CRHBP was 93.5% and 69.1%.Conclusions CRHBP can be the potential serum marker in diagnosing HCC.The detection rate can be improved by combined with the AFP.

关 键 词：肿瘤标志物 肝细胞肝癌 促肾上腺皮质素释放激素结合蛋白 联合检测 

分 类 号：R735.7[医药卫生—肿瘤]