p57kip-2和HSP90α在前列腺癌中的表达及其临床意义  

Expressions and clinical significance of p57kip-2 and HSP90α in prostate cancer

作　　者：李旭祥[1] 黄柳娜[1] 

机构地区：[1]广西壮族自治区百色市人民医院病理科,533000

出　　处：《中国实用医刊》2017年第11期95-98,共4页Chinese Journal of Practical Medicine

摘　　要：目的 探讨p57kip-2和热休克蛋白90α（Hsp90α）在前列腺癌中的表达,并研究临床生物学行为与病理的关系.方法 应用免疫组化SP法检测51例前列腺癌组织和51例正常前列腺组织中p57kip-2和HSP90α基因蛋白的表达,结合病例随访临床资料并分析其临床意义.结果 p57kip-2蛋白在前列腺癌中低表达,HSP90α蛋白在前列腺癌中高表达,与正常前列腺组织比较差异均有统计学意义（P〈0.05）;p57kip-2、HSP90α蛋白的表达强度与前列腺癌的Gleason评分有相关性（P〈0.05）,但与血清PSA和年龄无相关性（P〉0.05）;复发组与无复发组p57kip-2和HSP90α蛋白在前列腺癌中的表达率比较差异有统计学意义（P〈0.05）;p57kip-2蛋白与HSP90α蛋白在前列腺癌中的表达呈负相关（r=-0.627, P〈0.01）.结论 p57kip-2、HSP90α的表达可能与前列腺癌的恶性程度和预后有关,联合检测p57kip-2、HSP90α蛋白的表达对前列腺癌的良恶性程度及预后判断可能有重要的参考意义.Objective To investigate the expression and significance of p57kip-2 and HSP90α protein in prostate cancer, and study the relationship between the clinical biological behavior and pathology.Methods The protein expressions of p57kip-2 and HSP90α were detected in 51 cases of prostate cancer and 51 cases of normal prostate tissue with S-P immunohistochemical method, integrating with the following up data were analyzed.Results Compared with normal prostate tissue, p57kip-2 were low expressed and HSP90α were highly expressed in prostate cancer（P〈0.05）.The expression of p57kip-2 and HSP90α protein were related to Gleason histologic grading of prostate carcinoma（P〈0.05）, but there was no significant difference in age or PSA（P〉0.05）;There was significant difference in the p57kip-2 and HSP90α expression rate between with and without recurrence groups （P〈0.05）.pt7kip-2 protein was negatively correlated with HSP90α protein （r=-0.627, P〈0.01）.Conclusions The expressions of p57kip-2 and HSP90α protein may be related to malignant degree and prognosis of prostate cancer.Determination of p57kip-2 and HSP90α protein might be of great significance in the diagnosis of benign and malignant degree and prognosis of prostate cancer.

关 键 词：前列腺癌 p57kip-2 热休克蛋白90Α 免疫组织化学 

分 类 号：R737.25[医药卫生—肿瘤]