Spontaneous DNA damage propels tumorigenicity  

作　　者：Ilio Vitale Guido Kroemer 

出　　处：《Cell Research》2017年第6期720-721,共2页细胞研究（英文版）

摘　　要：High levels of endogenously gen- erated DNA damage drive oncogen- esis, sustain malignant progression and increase therapy resistance. In a paper recently published in Cell Research, Liu and colleagues added additional insights into this topic by uncovering a novel intrinsic source of double-strand breaks that fosters the aggressiveness and sternness of malignant cells.

关 键 词：DNA损伤 损伤机制 双链断裂 性基因 侵袭性 恶性 细胞 

分 类 号：Q523[生物学—生物化学] Q344.2