创伤后应激障碍患者的血清细胞因子相关性  

Serum Levels of Cytokines Associated with Posttraumatic Stress Disorder

作　　者：高允锁[1] 王小丹[2] 郭敏[1] 林展[1] 周家彬[1] 范春玲[1] 郭骏成 刘锋[1] 

机构地区：[1]海南省人民医院,海南海口570311 [2]海南医学院 [3]华南大学

出　　处：《中国健康心理学杂志》2017年第6期806-808,共3页China Journal of Health Psychology

基　　金：海南省国际科技合作专项(编号:kjhz2014-09);国家自然科学基金(编号:81260209);海南省重点科技项目(编号:Zdxm20130073)

摘　　要：目的:探讨海南地区创伤后应激障碍(PTSD)与血清细胞因子的相关性。方法:选择海南地区创伤后应激障碍患者和健康对照者各57例,应用酶联免疫吸附法(ELISA)检测血清中IL-2、IL-4、IL-6、IL-8含量。结果:创伤后应激障碍组血清中IL-2(t=16.017,P=0.000)、IL-6(t=21.292,P=0.000)、IL-8(t=7.006,P=0.000)含量显著高于对照组。两组人群血清中IL-4含量差异无统计学意义。结论:创伤后应激障碍与血清细胞因子含量的变化息息相关,IL-2、IL-6、IL-8可能在PTSD的发病机理中起着重要作用。Objective：To study the correlation of post-traumatic stress disorder and serum levels of cytokines in Hainan area.Methods：The patients with post-traumatic stress disorder and healthy controls each 57 in Hainan area were selected,we used the method of enzyme-linked immunosorbent（ELISA）to test IL-2,IL-4,IL- 6,IL-8 levels.Results：Serum IL-2 （t =16.017,P =0.000）,IL-6 （t =21.292,P =0.000）,IL-8 （t =7.006,P =0.000）in post-traumatic stress disorder group was significantly higher than that in the control group.There was no statisti-cally significant difference in IL-4 between the two groups.Conclusion：Post-traumatic stress disorder is closely re-lated to the change of the serum levels of cytokines.IL-2,IL-6,IL-8 may play an important role in the pathogen-esis of PTSD.

关 键 词：创伤后应激障碍 细胞因子 前炎性细胞因子 抗炎性细胞因子 

分 类 号：R749.5[医药卫生—神经病学与精神病学]