缺血性脑血管病患者血脂、同型半胱氨酸水平的变化  

Change of serum lipids and homocysteine levels in patients with ischemic cerebrovascular disease

作　　者：李荣华[1] 韦四友 黄骥[1] 管萍[1] 朱舟 田代实 康慧聪 

机构地区：[1]湖北省天门市第一人民医院神经内科,湖北天门431700 [2]武汉同济医院神经内科,湖北武汉430030

出　　处：《实用临床医药杂志》2017年第11期18-20,共3页Journal of Clinical Medicine in Practice

基　　金：国家中医药管理局课题[SATCM-2015-XXBZ(012)]

摘　　要：目的分析缺血性脑血管病患者血脂、同型半胱氨酸水平的变化。方法选取缺血性脑血管病(ICVD)患者150例为ICVD组,依据其病情分为短暂脑缺血发作(TIA)组和脑梗死(CI)组,另选择35例健康体检者为对照组。分析4组患者的相关血脂指标及血浆同型半胱氨酸指标。结果 ICVD组、TIA组、CI组与对照组患者的Hcy比较有显著差异(P<0.05)。3组叶酸指标与对照组比较无显著差异(P>0.05)。3组与对照组患者的TC、TG与HDL-C指标比较无显著差异(P>0.05),而LDL-C指标与对照组比较有显著差异(P<0.05)。3组与对照组患者的Apo A1与Apo B对比无显著差异(P>0.05),而Fg指标与对照组对比有显著差异(P<0.05)。结论缺血性脑血管病患者定期检测血清Hcy水平和相关血脂,对预防和干预缺血性脑血管病有较大的诊断价值。Objective To analyze the change of serum lipids and homocysteine level in patients with ischemie cerebrovascular disease. Methods A total of 150 patients with ischemic cerebro- vascular disease （ICVD） were selected as ICVD group, and the patients were divided into short-term cerebral isehemia （TIA） group and cerebral infarction group （CI） group. Another 35 healthy people were selected as control group. Blood lipid index and plasma homocysteine level were compared among 4 groups. Results There was significant difference of Hcy between ICVD group, TIA group, CI group and control group （ P 〈 0.05 ）. There was no significant difference of folie acid among the four groups （P 〉 0.05）. There were no significant differences in TC, TG and HDL-C between ICVD group, TIA group, C1 group and control group （P 〉 0.05 ） , but there was significant difference in LDL-C （P 〈 0.05）. There were no significant differences in ApoA1 and ApoB between ICVD group, TIA group, CI group and control group （P 〉 0.05 ）, and there was significant difference in Fg （P 〈 0.05 ）. Conclusion Periodic detections of serum Hcy and blood lip index has a great value in prevention and treatment of patients with ischemic cerebrovascular disease.

关 键 词：缺血性脑血管 血脂 同型半胱氨酸 诊断价值 

分 类 号：R743[医药卫生—神经病学与精神病学]