阑尾神经内分泌肿瘤的临床病理特征与预后分析  

Clinical pathological characteristics and prognosis of neuroendocrine tumors of the appendix

作　　者：肖应泽[1] 班东杰[1] 王丹[2] 魏建明[3] 

机构地区：[1]天津市公安医院普外科,300000 [2]天津医科大学总医院病理科 [3]天津医科大学总医院普外科

出　　处：《中华普通外科杂志》2017年第6期477-480,共4页Chinese Journal of General Surgery

摘　　要：目的探讨阑尾神经内分泌肿瘤的临床病理表现、诊断要点、治疗方法及预后。方法对天津市公安医院2006年6月至2016年6月收治的42例阑尾神经内分泌肿瘤患者的临床病理资料进行回顾性分析，依照2010年WHO消化系统肿瘤分类标准分级建议对肿瘤进行命名、分级、分期。结果本组42例阑尾神经内分泌肿瘤中男27例，女15例，中位年龄为60岁；肿瘤位于阑尾顶部37例，体部2例，基底部3例；肿瘤中位直径为1.2 cm；G1 17例，G2 21例，G3 4例。所有患者均获得随访，中位生存时间为17个月，1年生存率为92%。病理学检查细胞呈腺样或者玫瑰花样。结论阑尾神经内分泌肿瘤患者的临床表现无特异性，其确诊依赖于病理学和免疫组织化学检查，不同分级对其预后影响不同。Objective To explore the clinical pathological characteristics and prognostic factors of patients with neuroendocrine tumor of the appendix. Methods Data of 42 cases of the appendiceal neuroendocrine tumor from June 2006 to June 2016 at Tianjin Police Hospital were analyzed. Tumors were classified according to 2010 WHO classification. The survival curves were drawn using Kaplan-Meier method. Univariate analysis was performed by the Log-rank test. Results There were 27 males and 15 females, with median age of 60 years. Tumors located in the head of the appendix in 37 cases, in the body in 2 cases and at the base in 3 cases. The median of tumor sizes were 1.2 cm. G1 in 17 cases, G2 in 21 cases, G3 in 4 cases. The follow-up rate was 100%. The overall 1-year survival rate was 92%. Conclusions The clinical symptoms of appendiceal neuroendocrine tumors are most often nonspecific. The diagnosis depends on pathological examination and immunohistochemistry, and prognosis varies with pathological grades.

关 键 词：神经内分泌肿瘤 阑尾肿瘤 病理学 临床 预后 

分 类 号：R735.36[医药卫生—肿瘤]