健脾益气、补肾填精方联合奥沙利铂+CF/5-FU方案治疗大肠癌的疗效观察  

Observation on curative effect of invigorating spleen qi, bushen fillixi combined with oxaliplatin＋CF/5-FU on colorectal cancer

作　　者：徐玉芬[1] 宋斌斌[1] 李侠[1] 王爱芬[1] 徐晓芳[1] 周强[1] 江一鸣[1] 杨新妹[1] XU Yu-fen SONG Bin-bin LI Xia WANG Ai-fen XU Xiao-fang ZHOU Qiang JIANG Yi-ming YANG Xin-mei(Department of Oncology, Jiaxing First Hospital, Jiaxing 314000, China)

机构地区：[1]浙江省嘉兴市第一医院肿瘤科

出　　处：《中国生化药物杂志》2017年第6期74-75,共2页Chinese Journal of Biochemical Pharmaceutics

基　　金：浙江省中医药科技计划项目(2015ZQ034);浙江省医药卫生科技计划项目(2016KYB290);嘉兴市重点学科(肿瘤)项目(04-F-14)

摘　　要：目的 总结探讨健脾益气、补肾填精方联合奥沙利铂＋CF/5-FU方案治疗大肠癌的疗效观察.方法 选择2014年1月-2015年12月期间在浙江省嘉兴市第一医院接受治疗的80例大肠癌患者为研究对象,随机分为观察组和对照组各40例,其中对照组给予奥沙利铂＋CF/5-FU进行治疗,观察组在对照组治疗基础上应用健脾益气、补肾填精方治疗,观察2组治疗前后血清肿瘤标志物、临床症状及生活状态、变化,记录不良反应情况. 结果 观察组有效率82.50%,明显高于对照组62.50%;治疗后观察组的QOL评分（37.8±5.6）明显高于对照组（33.5±3.1）;观察组不良反应发生率30.00%,明显低于对照组52.50%,组间差异有统计学意义（P〈0.05）. 结论 健脾益气、补肾填精方联合奥沙利铂＋CF/5-FU方案治疗大肠癌效果显著,能有效改善临床症状和提高患者生活质量.Objective To investigate the therapeutic effect of Jianpi Yiqi, Bushen Fenjing combined with oxaliplatin＋CF/5-FU on colorectal cancer.MethodsEighty patients with colorectal cancer who were treated in our hospital from January 2014 to December 2015 were randomly divided into observation group（40cases） and control group （40cases）.The control group was given oxaliplatin＋CF/5-FU treatment, the observation group in the control group based on the application of Spleen Qi, Bushen fill essence treatment, observed before and after treatment of two groups of serum tumor markers, clinical symptoms and living conditions, changes, record adverse reactions.ResultsThe observation effect of 82.50% was significantly higher than that of the control group （62.50%）.The QOL score （37.8±5.6） was significantly higher than that of the control group （33.5±3.1） and the adverse reaction rate was 30.00% （P〈0.05）.The difference between the two groups was significant （P〈0.05）.ConclusionThe effect of invigorating spleen qi and tonifying siren solution combined with oxaliplatin＋CF/5-FU on colorectal cancer can improve the clinical symptoms and improve the quality of life of patients.

关 键 词：健脾益气 补肾填精 奥沙利铂 大肠癌 

分 类 号：R735.3[医药卫生—肿瘤]