通络止痛胶囊联合卡马西平治疗三叉神经痛的临床效果观察  

Observation on the clinical effect of tongluozhitong capsule combined with carbamazepine on the treatment of trigeminal neuralgia

作　　者：戴美芬 李世军 徐冬娟 张为强 李鸿飞 胡远超 DAI Mei-fen LI Shi-jun XU Dong-juan ZHANG Wei-qiang LI Hong-fei HU Yuan-chao(Department of Neurology, Dongyang People＇s Hospital, Dongyang 322100, China)

机构地区：[1]东阳市人民医院神经内科

出　　处：《中国生化药物杂志》2017年第6期204-206,共3页Chinese Journal of Biochemical Pharmaceutics

摘　　要：目的 观察通络止痛胶囊联合卡马西平治疗三叉神经痛的临床效果.方法 纳入2012年1月-2014年5月东阳市人民医院收治的三叉神经痛患者94例,按随机数字表法分为观察组和对照组,各47例.对照组给予卡马西平治疗,观察组患者在对照组基础上加用通络止痛胶囊联合治疗.记录并分析2组患者治疗前和治疗后2周以及4周的VAS评分、治疗疗效和不良反应比例,另外随访患者治疗半年和1年后的复发情况.结果 ①观察组治疗后2周和治疗后4周的VAS评分分别为（3.78±0.44）、（2.01±0.23）分,均低于对照组（5.96±0.53）、（4.02±0.38）分,且差异均具有统计学意义（P〈0.05）.②观察组治疗后4周的总有效率为95.74%,显著高于对照组78.72%,且差异具有统计学意义（P〈0.05）;③观察组治疗后4周不良反应率为21.28%,和对照组27.66%相比,差异无统计学意义;④观察组治疗后6个月和治疗后1年的复发率分别为6.38%和10.64%,显著低于对照组23.40%和29.79%,且差异均具有统计学意义（P〈0.05）.结论 通络止痛胶囊联合卡马西平治疗三叉神经痛可有效降低患者疼痛程度,降低患者复发率,且不会增加患者的不良反应,是一种安全有效的治疗方案.Objective To observe the clinical effect of tongluozhitong capsule combined with carbamazepine on the treatment of trigeminal neuralgia.Methods94 patients with trigeminal neuralgia from January 2012 to May 2014 in Dongyang people＆#39;s hospital were randomized double-blindly divided into the control group and the observation group, 47 cases in each group.The control group received carbamazepine treatment, and the observation group received tongluozhitong capsule combined with carbamazepine.VAS score, the effect and adverse reaction were recorded and analyzed before treatment, atwo weeks and four weeks after.Recurrence was followed-up a half and one year after treatment.Results①VAS scores in the observation group 2 weeks and 4 weeks after treatment were （3.78±0.44）, （2.01±0.23） points separately, which were lower than those in the control group （5.96±0.53）, （4.02±0.38） points separately, and the differences were statistically significant （P〈0.05）.②The total effective rate in the observation group 4 weeks after treatment was 95.74%, which significantly higher than that in the control group 78.72%, and the difference was statistically significant （P〈0.05）.③ The adverse reactions in the observation group 4 weeks after treatment was 21.28%, 27.66% in the control group, the difference was not significant;④ The recurrence rate in the observation group six months and one year after treatment were 6.38% and 10.64%, which significantly lower than those in the control group 23.40% and 29.79%, and the differences were statistically significant （P〈0.05）.ConclusionIt can effectively relieve pain, reduce the recurrence rate, and will not increase the adverse reactions which tongluozhitong capsule combined with carbamazepine were used on the treatment of trigeminal neuralgia.It is a safe and effective treatment program.

关 键 词：通络止痛胶囊 卡马西平 三叉神经痛 

分 类 号：R745.1[医药卫生—神经病学与精神病学]