沙利度胺片联合雷公藤多苷片治疗口腔扁平苔藓的效果观察  

Effect observation of Thalidomide Tablets combined with Tripterygium Glycosides tablets treating oral lichen planus

作　　者：陈梅花[1] 黄晓青[1] 

机构地区：[1]广州医科大学附属口腔医院药剂科,广东广州510140

出　　处：《中国当代医药》2017年第17期127-129,共3页China Modern Medicine

摘　　要：目的探讨沙利度胺片联合雷公藤多苷片治疗口腔扁平苔藓的效果。方法以我院2014年9月~2016年10月牙周黏膜收治的108例口腔扁平苔藓患者为研究对象,按就诊号末位单双数分为常规组(局部注射曲安奈德)、观察组(用药沙利度胺、雷公藤多苷),每组54例。比较两组的治疗效果,疼痛、糜烂评分,不良反应发生率。结果观察组的有效率为96.3%,高于对照组的87.0%(P<0.05)。入院时疼痛、糜烂评分组间比较差异无统计学意义(P>0.05),观察组服药后的疼痛、糜烂评分低于对照组(P<0.05)。观察组的不良反应发生率为7.4%,低于对照组的16.7%(P<0.05)。结论沙利度胺片联合雷公藤多苷片治疗口腔扁平苔藓的效果较好。Objective To investigate the effect of Thalidomide Tablets combined with Tripterygium Glycosides tablets treating oral lichen planus.Methods 108 patients with oral lichen planus admitted into periodontics oral department from September 2014 to October 2016 were selected as study object and they were divided into the routine group（injected with Triamcinolone Acetonide locally） and observation group（treated with the drugs of Thalidomide combined with Tripterygium） according to the end of single or double numbers of visiting numbers and there were 54 cases in each group.The treatment effect,pain and erosion score and incidence of adverse reactions were compared between the two groups.Results The effective rate of the observation group was 96.3%,which was higher than that of the control group（87.0%）（P〈0.05）.There was no significant difference in pain and erosion score between the groups on admission（P〉0.05）,and the score of pain and erosion in the observation group were lower than those in the control group（P〈0.05）.The incidence of adverse reactions in the observation group was 7.4%,which was lower than that of the control group（16.7%）（P〈0.05）.Conclusion The effect of Thalidomide Tablets combined with Tripterygium Glycosides tablets is better in the treatment of oral lichen planus.

关 键 词：沙利度胺 口腔扁平苔藓 雷公藤多苷 

分 类 号：R781.5[医药卫生—口腔医学]