红景天苷对急性脑梗死尿激酶静脉溶栓患者早期再灌注的保护作用分析  

Protective effect of salidroside on early reperfusion in patients with acute cerebral infarction treated with urokinase intravenous thrombolysis

作　　者：李青[1] 陈悦[2] 高万峰[3] Li Qing Chen Yue Gao Wanfeng(Department of Pharmacy,Armed Police Corps Hospital in Liaoning,Shenyang,Liaoning l lO034,China（ Li Q Department of Cardiology,Armed Police Corps Hospital in Liaoning, Shenyang, Liaoning 110034, China（ Chen Y Department of Surgery,Armed Police Corps Hospital in Liaoning, Shenyang, Liaoning 110034, China （ Gao WF)

机构地区：[1]武警辽宁省总队医院药剂科,辽宁省沈阳110034 [2]武警辽宁省总队医院心内科,辽宁省沈阳110034 [3]武警辽宁省总队医院外科,辽宁省沈阳110034

出　　处：《中国基层医药》2017年第13期1969-1973,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 探讨红景天苷对急性脑梗死尿激酶静脉溶栓患者早期再灌注的保护作用.方法 将符合静脉溶栓指标的98例急性脑梗死患者为研究对象,采用密封信封法按1：1随机分为对照组和治疗组,对照组在脱水、抗凝、脑康复、调血压、血糖等常规治疗的基础上,给予尿激酶静脉溶栓治疗,治疗组在对照组治疗基础上给予红景天注射液治疗,治疗10 d.观察两组治疗前后血清丙二醛（MDA）、超氧化物歧化酶（SOD）、血浆内皮素1（ET-1）、超敏C反应蛋白（hs-CRP）、神经功能缺损评分（NIHSS）、Barthel指数的变化以及临床效果.结果 两组MDA、SOD、ET-1、hs-CRP含量,NIHSS和Barthel指数在治疗前差异均无统计学意义（t=0.30、0.26、0.41、004、0.57、0.33,均P〉0.05）;治疗后,对照组和治疗组MDA分别为（7.54±1.14）nmol/mL和（6.04±1.21）nmol/mL,SOD（92.42±15.28）U/mL和（108.54±19.24）U/mL,ET-1（64.5±7.4）pg/mL和（41.4±8.1）pg/mL,hs-CRP（3.84±1.04）μmol/L和（2.54±0.84）μmol/L,NIHSS评分（16.5±5.4）分和（11.2±3.1）分,Barthel指数（62.1±12.4）和（71.4±10.4）,两组治疗后各指标差异均有统计学意义（t=6.31、4.59、14.74、6.81、5.96、4.02,均P〈0.01）;治疗组总有效率为91.84%,对照组为69.39%,两组差异有统计学意义（χ2=8.83,P〈0.05）.结论 红景天苷有改善急性脑梗死患者脂质过氧化作用,促进氧化自由基分解,减轻体内炎性反应,改善神经功能和生活质量,对急性脑梗死患者尿激酶静脉溶栓早期再灌注具有保护作用.Objective To explore the protective effect of salidroside on early reperfusion in patients with acute cerebral infarction treated with urokinase intravenous thrombolysis.Methods 98 patients with acute cerebral infarction who were consistent with intravenous thrombolysis after screening were enrolled in the study.They were equally divided into the control group and the treatment group by sealed envelop method in one to one ratio.The control group received urokinase intravenous thrombolytic therapy on the basis of dehydration,anticoagulation,brain rehabilitation,regulating blood pressure,blood glucose and other conventional treatment.Based on the treatment in the control group,the treatment group was treated with Hongjingtian injection for 10 days.The serum malondialdehyde（MDA）,superoxide dismutase（SOD）,plasma endothelin-1（ET-1） and high sensitive C-reactive protein（hs-CRP）,neurological deficit score（NIHSS）,Barthel index and clinical effect in the two groups were observed.Results There were no significant differences in levels of MDA,SOD,ET-1,hs-CRP,NIHSS and Barthel index between the two groups before treatment （t=0.30,0.26,0.41,004,0.57,0.33,all P〉0.05）.After treatment,there were statistically significant differences between the control group and the treatment group in levels of MDA,SOD,ET-1,hs-CRP,NIHSS score and Barthel index[（7.54±1.14）nmol/mL vs.（6.04±1.21）nmol/mL,（92.42±15.28）U/mL vs.（108.54±19.24）U/mL,（64.5±7.4）pg/mL vs.（41.4±8.1）pg/mL,（3.84±1.04）μmol/L vs.（2.54±0.84）μmol/L,（16.5±5.4）points vs.（11.2±3.1）points,（62.1±12.4） vs.（71.4±10.4）]（t=6.31,4.59,14.74,6.81,5.96,4.02,all P〈0.01）.The total effective rate of the treatment group was 91.84%,which of the control group was 63.39%,the difference was statistically significant（χ2=8.83,P〈0.05）.Conclusion Salidroside can relieve lipid peroxidation in patients with acute cerebral infarction,promote decomposition of oxyradical,reduce inflammatory reactions,improve neu

关 键 词：红景天苷 脑梗死 尿激酶 静脉溶栓 早期再灌注 

分 类 号：R743.3[医药卫生—神经病学与精神病学]